TY - JOUR
T1 - Mechanism of TRADD and RIP in necroptosis of recurrent aphthous ulcers in inflammatory bowel disease
AU - Surboyo, Meircurius Dwi Condro
AU - Ernawati, Diah Savitri
AU - Sunariani, Jenny
N1 - Publisher Copyright:
© 2020 Connect Journal.
PY - 2020
Y1 - 2020
N2 - Recurrent aphthous ulcers (RAU) is an inflammatory and chronic ulcerative condition that occur in the oral mucosa as a result of mechanical trauma or manifestation of inflammatory bowel disease (IBD) in the oral cavity. Necroptosis can be triggered by the death receptor ligand which is derived from a variety of extracellular and intracellular stimulus that induce the expression or activation family of death receptor ligands like tumor necrosis factor alpha receptor 1 (TNFR1). TNFR1 bond with specific ligands, TNF-α, cause the interaction with intracellular adapter protein called TNFR-associated death domain (TRADD). TRADD can bind with FAS-associated death ligand (FADD) and receptor interacting protein kinase (RIP) result in necroptosis. The ulcer formation as a manifestation of IBD and RAU in the oral mucosa is due to cell death due to changes in inflammatory cytokine factors, such as TNF-α, in the oral mucosal and intestinal epithelium which activate TRADD and RIP3. The aims of this review articles are explained the role of TRADD and RIP in necroptosis occur at IBD induced RAU.
AB - Recurrent aphthous ulcers (RAU) is an inflammatory and chronic ulcerative condition that occur in the oral mucosa as a result of mechanical trauma or manifestation of inflammatory bowel disease (IBD) in the oral cavity. Necroptosis can be triggered by the death receptor ligand which is derived from a variety of extracellular and intracellular stimulus that induce the expression or activation family of death receptor ligands like tumor necrosis factor alpha receptor 1 (TNFR1). TNFR1 bond with specific ligands, TNF-α, cause the interaction with intracellular adapter protein called TNFR-associated death domain (TRADD). TRADD can bind with FAS-associated death ligand (FADD) and receptor interacting protein kinase (RIP) result in necroptosis. The ulcer formation as a manifestation of IBD and RAU in the oral mucosa is due to cell death due to changes in inflammatory cytokine factors, such as TNF-α, in the oral mucosal and intestinal epithelium which activate TRADD and RIP3. The aims of this review articles are explained the role of TRADD and RIP in necroptosis occur at IBD induced RAU.
KW - Inflammatory bowel disease
KW - Necroptosis
KW - RAU
KW - TRADD and RIP
UR - http://www.scopus.com/inward/record.url?scp=85090779689&partnerID=8YFLogxK
U2 - 10.35124/bca.2020.20.S1.2951
DO - 10.35124/bca.2020.20.S1.2951
M3 - Review article
AN - SCOPUS:85090779689
SN - 0972-5075
VL - 20
SP - 2951
EP - 2955
JO - Biochemical and Cellular Archives
JF - Biochemical and Cellular Archives
ER -