Coping is a cognitive process and behavior that aims at reducing depression while facing stress situation. Treating patient with schizophrenia is a stressor for family and the family will tend to undergo pressure situation from either the environment or the inside part until it can influence family-coping in treating family who suffers mental disorder, such as schizophrenia. Moreover, this research aimed at knowing factors that influenced mechanism of family-coping in treating patient with schizophrenia. Data analysis utilized logistic-regression-test. The result showed that the factors that influenced against family-coping were self-esteem and social-support, meanwhile, the factors that did not influence it were knowledge, stress, and patient’s behavior in social-isolation.