TY - JOUR
T1 - Maternal cardiovascular risk in five years after labor with early-and late-onset of severe preeclampsia
AU - Aditiawarman,
AU - Ernawati,
AU - Joewono, Hermanto Tri
AU - Akbar, Muhammad Ilham Aldika
AU - Zulhijayanti, Noor Assyifa
AU - Suryawan, I. Gde Rurus
N1 - Publisher Copyright:
© 2020, Advanced Scientific Research. All rights reserved.
PY - 2020/10/1
Y1 - 2020/10/1
N2 - Preeclampsia still becomes an important topic related to cardiovascular system health in more than 300 million women worldwide and has both short-term and long-term morbidity. This study aimed to learn maternal cardiovascular risk after 5 years after the diagnosis of early-and late-onset of severe preeclampsia. A retrospective cohort study involved all women meeting the inclusion criteria, who treated from January 2013 to January 2014, with early-and late-onset of severe preeclampsia diagnosis and get pregnancy termination in Dr. Soetomo General Hospital, Surabaya. The mean age of the subjects was in the range of 20-35 years, where age in the early-onset of severe preeclampsia group was older than the late-onset ones (32.12±6.827 years vs 28.2±7.890 years). There was a higher and significant cardiovascular risk factor related to hypertension and/or metabolic syndrome (p = 0.031) in the early-onset of severe preeclampsia group and supported an increase of 1.47 times cardiovascular risk factors (RR 1.471; CI 95 [1.071-2.019]) compared to the late-onset of severe preeclampsia group. The body mass index (BMI) and waist circumference of subjects were found higher in early-onset of severe preeclampsia (28.176±4.342 kg/m2 vs 25.892±3.956 kg/m2; 90.47±9.288 cm vs 83.48±9.283 cm). The maternal cardiovascular risks were hypertension and metabolic syndrome, which are more severe in the early onset of severe preeclampsia compared to the late-onset at 5 years after diagnosis.
AB - Preeclampsia still becomes an important topic related to cardiovascular system health in more than 300 million women worldwide and has both short-term and long-term morbidity. This study aimed to learn maternal cardiovascular risk after 5 years after the diagnosis of early-and late-onset of severe preeclampsia. A retrospective cohort study involved all women meeting the inclusion criteria, who treated from January 2013 to January 2014, with early-and late-onset of severe preeclampsia diagnosis and get pregnancy termination in Dr. Soetomo General Hospital, Surabaya. The mean age of the subjects was in the range of 20-35 years, where age in the early-onset of severe preeclampsia group was older than the late-onset ones (32.12±6.827 years vs 28.2±7.890 years). There was a higher and significant cardiovascular risk factor related to hypertension and/or metabolic syndrome (p = 0.031) in the early-onset of severe preeclampsia group and supported an increase of 1.47 times cardiovascular risk factors (RR 1.471; CI 95 [1.071-2.019]) compared to the late-onset of severe preeclampsia group. The body mass index (BMI) and waist circumference of subjects were found higher in early-onset of severe preeclampsia (28.176±4.342 kg/m2 vs 25.892±3.956 kg/m2; 90.47±9.288 cm vs 83.48±9.283 cm). The maternal cardiovascular risks were hypertension and metabolic syndrome, which are more severe in the early onset of severe preeclampsia compared to the late-onset at 5 years after diagnosis.
KW - Cardiovascular risk
KW - Early-onset of severe preeclampsia
KW - Hypertension
KW - Late-onset of severe preeclampsia
KW - Metabolic syndrome
KW - Preeclampsia
UR - http://www.scopus.com/inward/record.url?scp=85089875977&partnerID=8YFLogxK
U2 - 10.31838/ijpr/2020.12.04.196
DO - 10.31838/ijpr/2020.12.04.196
M3 - Article
AN - SCOPUS:85089875977
SN - 0975-2366
VL - 12
SP - 1401
EP - 1407
JO - International Journal of Pharmaceutical Research
JF - International Journal of Pharmaceutical Research
IS - 4
ER -