TY - JOUR
T1 - Mangrove Ethanol Extract (Aegiceras corniculatum) Failed to Inhibit Candida albicans Growth Isolated from Oral Candidiasis HIV/AIDS patient in vitro
AU - Saputra, Gustiadi
AU - Nugraha, Alexander Patera
AU - Rosari, Fransisca Shancti
AU - Budhy, Theresia Indah
AU - Ernawati, Diah Savitri
AU - Sibero, Mada Triandala
AU - Nugraha, Albertus Putera
AU - Ramadhani, Nastiti Faradilla
AU - Noor, Tengku Natasha Eleena binti Tengku Ahmad
N1 - Funding Information:
We are extremely grateful to Mr. Eta Radhianto of the Dental Research Center, Faculty of Dental Medicine Airlangga University, the Faculty of Pharmacy, Widya Mandala Catholic University, for their assistance and thoughtful guidance with this research.
Publisher Copyright:
© 2022, Journal of International Dental and Medical Research. All Rights Reserved.
PY - 2022
Y1 - 2022
N2 - Candida albicans species can cause severe morbidity and mortality in Human Immunodeficiency Virus (HIV) patients when they become systemically involved, known as candidemia. Mangrove (Aegiceras corniculatum) is a plant that is commonly distributed and has been shown to have several advantages to be used as phytotherapy. Objective to investigate the anti-fungal ability of Mangrove Ethanol Extract (MEE) (A.corniculatum) to Candida albicans isolated from Oral Candidiasis HIV/AIDS patient in vitro. The fresh mangrove leaf (A. corniculatum) was extracted by means of maceration methods. There were 5 groups, each with 4 samples: (1) control negative group (2) control doxycycline group, (3) MEE (A. corniculatum) concentration 25%, (3) 50% concentration group, (4) 75% concentration group, and (5) 100% concentration group. C. albicans isolated from stadium HIV/AIDS patients who were assessed clinically but did not seek fungal infection therapy. Saboraoud dextrose agar (SDA) containing the tested C. albicans suspension was poured into a petri dish around the paper disk. Observation of the inhibition zone around the well and then measuring the diameter of the inhibition zone horizontally and vertically using a digital scale ruler. It was discovered that 100%, 75%, 50%, and 25% MEE (A corniculatum) had no antifungal efficacy against C. albicans isolated from HIV/AIDS with no significant difference in inhibitory zone (p>0.05). MEE (A. corniculatum) did not have an inhibitory zone against C. albicans isolated from HIV/AIDS patients in vitro.
AB - Candida albicans species can cause severe morbidity and mortality in Human Immunodeficiency Virus (HIV) patients when they become systemically involved, known as candidemia. Mangrove (Aegiceras corniculatum) is a plant that is commonly distributed and has been shown to have several advantages to be used as phytotherapy. Objective to investigate the anti-fungal ability of Mangrove Ethanol Extract (MEE) (A.corniculatum) to Candida albicans isolated from Oral Candidiasis HIV/AIDS patient in vitro. The fresh mangrove leaf (A. corniculatum) was extracted by means of maceration methods. There were 5 groups, each with 4 samples: (1) control negative group (2) control doxycycline group, (3) MEE (A. corniculatum) concentration 25%, (3) 50% concentration group, (4) 75% concentration group, and (5) 100% concentration group. C. albicans isolated from stadium HIV/AIDS patients who were assessed clinically but did not seek fungal infection therapy. Saboraoud dextrose agar (SDA) containing the tested C. albicans suspension was poured into a petri dish around the paper disk. Observation of the inhibition zone around the well and then measuring the diameter of the inhibition zone horizontally and vertically using a digital scale ruler. It was discovered that 100%, 75%, 50%, and 25% MEE (A corniculatum) had no antifungal efficacy against C. albicans isolated from HIV/AIDS with no significant difference in inhibitory zone (p>0.05). MEE (A. corniculatum) did not have an inhibitory zone against C. albicans isolated from HIV/AIDS patients in vitro.
KW - Communicable disease
KW - Dentistry
KW - Hiv/aids
KW - Infectious disease
KW - Medicine
UR - http://www.scopus.com/inward/record.url?scp=85138175831&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:85138175831
SN - 1309-100X
VL - 15
SP - 1236
EP - 1241
JO - Journal of International Dental and Medical Research
JF - Journal of International Dental and Medical Research
IS - 3
ER -