Mangrove Ethanol Extract (Aegiceras corniculatum) Failed to Inhibit Candida albicans Growth Isolated from Oral Candidiasis HIV/AIDS patient in vitro

Candida albicans species can cause severe morbidity and mortality in Human Immunodeficiency Virus (HIV) patients when they become systemically involved, known as candidemia. Mangrove (Aegiceras corniculatum) is a plant that is commonly distributed and has been shown to have several advantages to be used as phytotherapy. Objective to investigate the anti-fungal ability of Mangrove Ethanol Extract (MEE) (A.corniculatum) to Candida albicans isolated from Oral Candidiasis HIV/AIDS patient in vitro. The fresh mangrove leaf (A. corniculatum) was extracted by means of maceration methods. There were 5 groups, each with 4 samples: (1) control negative group (2) control doxycycline group, (3) MEE (A. corniculatum) concentration 25%, (3) 50% concentration group, (4) 75% concentration group, and (5) 100% concentration group. C. albicans isolated from stadium HIV/AIDS patients who were assessed clinically but did not seek fungal infection therapy. Saboraoud dextrose agar (SDA) containing the tested C. albicans suspension was poured into a petri dish around the paper disk. Observation of the inhibition zone around the well and then measuring the diameter of the inhibition zone horizontally and vertically using a digital scale ruler. It was discovered that 100%, 75%, 50%, and 25% MEE (A corniculatum) had no antifungal efficacy against C. albicans isolated from HIV/AIDS with no significant difference in inhibitory zone (p>0.05). MEE (A. corniculatum) did not have an inhibitory zone against C. albicans isolated from HIV/AIDS patients in vitro.