Mangosteen skin (Gracinia mangostana L) as stem cell growth factor

Stem cells gave a new way to accelerate healing progress because the stem cells can be utilized for the treatment of various degenerative diseases including periodontitis. The number of stem cells is limited; therefore, a growth factor is needed to increase stem cell proliferation. Growth factor that has been used is still expensive and difficult to obtain so it is necessary to develop an alternative use of growth factors from natural materials that potentially accelerate wound healing. Mangosteen (Gracinia mangostana L) contains xanthones which are flavonoid compounds that can activate kinase protein, as growth factor stem cells. To discover the potential effect of mangosteen skin extract (Gracinia mangostana L) as growth factor of stem cells. Proliferative ability test of mangosteen skin (Gracinia mangostana L) as a growth factor for mesenchymal stem cell (MSC) using MTT assay with FGF comparator. Test of osteogenic differentiation using Alizarin Red coloring. Viability cells in MSC combined with higher mangosteen skin compared with MSC combined with FGF. After stem cells and mangosteen skin extracts were added the osteogenic induction medium, a presence of mineralization indicating differentiation into osteoblasts. The addition of mangosteen skin extract on MSC can increase the ability of proliferation and differentiation into osteoblasts from MSC.