TY - JOUR
T1 - Management and outcomes following emergency surgery for traumatic brain injury – A multi-centre, international, prospective cohort study (the Global Neurotrauma Outcomes Study)
AU - Clark, David
AU - Joannides, Alexis
AU - Ibrahim Abdallah, Omar
AU - Olufemi Adeleye, Amos
AU - Hafid Bajamal, Abdul
AU - Bashford, Tom
AU - Bhebhe, Arnold
AU - Biluts, Hagos
AU - Budohoska, Natalia
AU - Budohoski, Karol
AU - Cherian, Iype
AU - Marklund, Niklas
AU - Fernandez Mendez, Rocio
AU - Figaji, Tony
AU - Kumar Gupta, Deepak
AU - Iaccarino, Corrado
AU - Ilunga, Ali
AU - Joseph, Mathew
AU - Khan, Tariq
AU - Laeke, Tsegazeab
AU - Waran, Vicknes
AU - Park, Kee
AU - Rosseau, Gail
AU - Rubiano, Andres
AU - Saleh, Youssuf
AU - Shabani, Hamisi K.
AU - Smith, Brandon
AU - Sichizya, Kachinga
AU - Tewari, Manoj
AU - Tirsit, Abenezer
AU - Thu, Myat
AU - Tripathi, Manjul
AU - Trivedi, Rikin
AU - Villar, Sofia
AU - Devi Bhagavatula, Indira
AU - Servadei, Franco
AU - Menon, David
AU - Kolias, Angelos
AU - Hutchinson, Peter
N1 - Funding Information:
This research was commissioned by the National Institute for Health Research (NIHR) Global Health Research Group on Neurotrauma (16/137/105) using UK aid from the UK Government. Peter Hutchinson is supported by a Research Professorship from the National Institute for Health Research (NIHR), the NIHR Cambridge Biomedical Research Centre, a European Union Seventh Framework Program grant (CENTER-TBI; grant no. 602150) and the Royal College of Surgeons of England. The funder has not been involved in the drafting of this protocol or preparation of the manuscript.
Publisher Copyright:
© 2020 The Authors
PY - 2020
Y1 - 2020
N2 - Introduction: Traumatic brain injury (TBI) accounts for a significant amount of death and disability worldwide and the majority of this burden affects individuals in low-and-middle income countries. Despite this, considerable geographical differences have been reported in the care of TBI patients. On this background, we aim to provide a comprehensive international picture of the epidemiological characteristics, management and outcomes of patients undergoing emergency surgery for traumatic brain injury (TBI) worldwide. Methods and analysis: The Global Neurotrauma Outcomes Study (GNOS) is a multi-centre, international, prospective observational cohort study. Any unit performing emergency surgery for TBI worldwide will be eligible to participate. All TBI patients who receive emergency surgery in any given consecutive 30-day period beginning between 1st of November 2018 and 31st of December 2019 in a given participating unit will be included. Data will be collected via a secure online platform in anonymised form. The primary outcome measures for the study will be 14-day mortality (or survival to hospital discharge, whichever comes first). Final day of data collection for the primary outcome measure is February 13th. Secondary outcome measures include return to theatre and surgical site infection. Ethics and dissemination: This project will not affect clinical practice and has been classified as clinical audit following research ethics review. Access to source data will be made available to collaborators through national or international anonymised datasets on request and after review of the scientific validity of the proposed analysis by the central study team.
AB - Introduction: Traumatic brain injury (TBI) accounts for a significant amount of death and disability worldwide and the majority of this burden affects individuals in low-and-middle income countries. Despite this, considerable geographical differences have been reported in the care of TBI patients. On this background, we aim to provide a comprehensive international picture of the epidemiological characteristics, management and outcomes of patients undergoing emergency surgery for traumatic brain injury (TBI) worldwide. Methods and analysis: The Global Neurotrauma Outcomes Study (GNOS) is a multi-centre, international, prospective observational cohort study. Any unit performing emergency surgery for TBI worldwide will be eligible to participate. All TBI patients who receive emergency surgery in any given consecutive 30-day period beginning between 1st of November 2018 and 31st of December 2019 in a given participating unit will be included. Data will be collected via a secure online platform in anonymised form. The primary outcome measures for the study will be 14-day mortality (or survival to hospital discharge, whichever comes first). Final day of data collection for the primary outcome measure is February 13th. Secondary outcome measures include return to theatre and surgical site infection. Ethics and dissemination: This project will not affect clinical practice and has been classified as clinical audit following research ethics review. Access to source data will be made available to collaborators through national or international anonymised datasets on request and after review of the scientific validity of the proposed analysis by the central study team.
KW - Brain injuries
KW - Epidemiology
KW - Global health
KW - Injuries
KW - Neurosurgery
KW - Traumatic
UR - http://www.scopus.com/inward/record.url?scp=85081982002&partnerID=8YFLogxK
U2 - 10.1016/j.isjp.2020.02.001
DO - 10.1016/j.isjp.2020.02.001
M3 - Article
AN - SCOPUS:85081982002
SN - 2468-3574
VL - 20
SP - 1
EP - 7
JO - International Journal of Surgery Protocols
JF - International Journal of Surgery Protocols
ER -