TY - JOUR
T1 - Major Ocular Abnormalities Among Hemodialysis Patients in Indonesia
AU - Widjaja, Sauli Ari
AU - Ono, Koichi
AU - Hiratsuka, Yoshimune
AU - Yustiarini, Ima
AU - Widodo,
AU - Murakami, Akira
N1 - Funding Information:
This cross-sectional study was conducted at Hemodialysis (HD) Unit, Dr. Soetomo General Academic Hospital (DSGAH), Surabaya, Indonesia, in May-June 2019. This study was supported by the Universitas Airlangga Research Grant. An ethical clearance approval was obtained from the institutional review board of DSGAH (Komisi Etik Peneliti Kesehatan Rumah Sakit Dr. Soetomo No.1155/KEPK/V/2019). All subjects underwent regular HD, twice per week at the HD unit. Before subject recruitment, written informed consent was obtained from all the participants. All the procedures performed in this study were in accordance with the ethical standards of the institutional research committee and the Declaration of Helsinki.
Funding Information:
This study was supported by Universitas Airlangga Research Grant (Grant SK Rektor Unair No. 1408/UN3/2019).
Publisher Copyright:
© 2022, Indonesian Society of Internal Medicine. All rights reserved.
PY - 2022
Y1 - 2022
N2 - Background: This study aimed to identify the major ocular abnormality findings (i.e., cataract and conjunctival and corneal calcification (CCC)) among hemodialysis (HD) patients and their risk factors. Methods: A single institute-based cross-sectional study in Indonesia. Demographic data, medical histories, and complete ocular examinations were collected. For two major ocular abnormalities found, a generalized estimating equation was incorporated in a logistic regression model to assess the relationship with their risk factors. Results: We analyzed 318 eyes (159 individuals), of which 54.7% male and 45.3% female. The mean age was 51.6±11.3 years. The mean HD period was 3.5±3.2 years. Hypertension and diabetes mellitus (DM) was found in 81.1% and 34.6%, respectively. The major ocular abnormalities found were cataract (206 eyes; 64.78% (95% CI 59.53-70.03)), followed by CCC (135 eyes; 42.45% (95 % CI 37.02-47.88)). In a multivariate model, higher education (odds ratio (OR) 0.17; 95% CI 0.04-0.74), hypertension (OR 0.15; 95% CI 0.03-0.79), DM (OR 10.49; 95% CI 1.57-70.06), Systolic Blood Pressure (SBP) 120-129 mmHg (OR 0.05; 95% CI 0.003-0.69), SBP >140 mmHg (OR 0.05; 95% CI 0.004-0.67), Diastolic Blood Pressure (DBP) 80-89 mmHg (OR 7.44; 95% CI 1.13-48.73), and DBP >90 mmHg (OR 48.47; 95% CI 3.4-692.03) showed significant association with cataract. Meanwhile, there was no significant association between CCC and any predictor. Conclusion: Cataract and CCC were found to be the major ocular abnormalities among HD patients in this study, with DM and higher DBP as the risk factors for cataract. This finding supports recommendations for integrated regular eye screening in HD patients.
AB - Background: This study aimed to identify the major ocular abnormality findings (i.e., cataract and conjunctival and corneal calcification (CCC)) among hemodialysis (HD) patients and their risk factors. Methods: A single institute-based cross-sectional study in Indonesia. Demographic data, medical histories, and complete ocular examinations were collected. For two major ocular abnormalities found, a generalized estimating equation was incorporated in a logistic regression model to assess the relationship with their risk factors. Results: We analyzed 318 eyes (159 individuals), of which 54.7% male and 45.3% female. The mean age was 51.6±11.3 years. The mean HD period was 3.5±3.2 years. Hypertension and diabetes mellitus (DM) was found in 81.1% and 34.6%, respectively. The major ocular abnormalities found were cataract (206 eyes; 64.78% (95% CI 59.53-70.03)), followed by CCC (135 eyes; 42.45% (95 % CI 37.02-47.88)). In a multivariate model, higher education (odds ratio (OR) 0.17; 95% CI 0.04-0.74), hypertension (OR 0.15; 95% CI 0.03-0.79), DM (OR 10.49; 95% CI 1.57-70.06), Systolic Blood Pressure (SBP) 120-129 mmHg (OR 0.05; 95% CI 0.003-0.69), SBP >140 mmHg (OR 0.05; 95% CI 0.004-0.67), Diastolic Blood Pressure (DBP) 80-89 mmHg (OR 7.44; 95% CI 1.13-48.73), and DBP >90 mmHg (OR 48.47; 95% CI 3.4-692.03) showed significant association with cataract. Meanwhile, there was no significant association between CCC and any predictor. Conclusion: Cataract and CCC were found to be the major ocular abnormalities among HD patients in this study, with DM and higher DBP as the risk factors for cataract. This finding supports recommendations for integrated regular eye screening in HD patients.
KW - chronic kidney disease
KW - health-system
KW - hemodialysis
KW - ocular abnormality
KW - ocular manifestation
UR - http://www.scopus.com/inward/record.url?scp=85127878349&partnerID=8YFLogxK
M3 - Article
C2 - 35398826
AN - SCOPUS:85127878349
SN - 0125-9326
VL - 54
SP - 52
EP - 61
JO - Acta medica Indonesiana
JF - Acta medica Indonesiana
IS - 1
ER -
