MAGI-2 and scaffold proteins in glomerulopathy

Maulana A. Empitu, Ika N. Kadariswantiningsih, Masashi Aizawa, Katsuhiko Asanuma

Research output: Contribution to journalReview articlepeer-review

12 Citations (Scopus)

Abstract

In many cells and tissues, including the glomerular filtration barrier, scaffold proteins are critical in optimizing signal transduction by enhancing structural stability and functionality of their ligands. Recently, mutations in scaffold protein membrane-associated guanylate kinase inverted 2 (MAGI-2) encoding gene were identified among the etiology of steroid-resistant nephrotic syndrome. MA-GI-2 interacts with core proteins of multiple pathways, such as transforming growth factor-β signaling, planar cell polarity pathway, and Wnt/β-catenin signaling in podocyte and slit diaphragm. Through the interaction with its ligand, MAGI-2 modulates the regulation of apoptosis, cytoskeletal reorganization, and glomerular development. This review aims to summarize recent findings on the role of MAGI-2 and some other scaffold proteins, such as nephrin and synaptopodin, in the underlying mechanisms of glomerulopathy.

Original languageEnglish
Pages (from-to)F1336-F1344
JournalAmerican Journal of Physiology - Renal Physiology
Volume315
Issue number5
DOIs
Publication statusPublished - 29 Oct 2018

Keywords

  • Glomerulopathy
  • MAGI-2
  • Podocyte
  • Scaffold protein
  • Slit diaphragm

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