TY - JOUR
T1 - Macahuilettiin A, a new isoprenylated flavanone from the leaves of Macaranga hullettii King ex Hook and their antiplasmodial activity
AU - Saputri, Ratih Dewi
AU - Tukiran, Tukiran
AU - Wati, First Ambar
AU - Purnamasari, Amalia Putri
AU - Wardhana, Madya Wisnu
AU - Tjahjandarie, Tjitjik Srie
AU - Tanjung, Mulyadi
N1 - Publisher Copyright:
© 2024 Vietnam Academy of Science and Technology and Wiley-VCH GmbH.
PY - 2024
Y1 - 2024
N2 - A new isoprenylated flavanone, macahuilettiin A (1), along with lonchocarpol A (2) and nymphaeol C (3), were isolated from Macaranga hullettii King ex Hook leaves. Their structures were combined by UV, high-resolution ESI-TOFMS, 1D-, and 2D-NMR spectra analysis. Flavanones 1–3 were assayed for antiplasmodial activity toward Plasmodium falciparum 3D7, which was carried out using the Trager and Jansen method, showing that the IC50 values for flavanones 1–3 were 0.15, 1.64, and 0.61 µm, respectively, which is classified as high activity.
AB - A new isoprenylated flavanone, macahuilettiin A (1), along with lonchocarpol A (2) and nymphaeol C (3), were isolated from Macaranga hullettii King ex Hook leaves. Their structures were combined by UV, high-resolution ESI-TOFMS, 1D-, and 2D-NMR spectra analysis. Flavanones 1–3 were assayed for antiplasmodial activity toward Plasmodium falciparum 3D7, which was carried out using the Trager and Jansen method, showing that the IC50 values for flavanones 1–3 were 0.15, 1.64, and 0.61 µm, respectively, which is classified as high activity.
KW - Macaranga hullettii
KW - antiplasmodial
KW - flavanone
KW - macahuilettiin A
UR - http://www.scopus.com/inward/record.url?scp=85190943342&partnerID=8YFLogxK
U2 - 10.1002/vjch.202300417
DO - 10.1002/vjch.202300417
M3 - Article
AN - SCOPUS:85190943342
SN - 2572-8288
JO - Vietnam Journal of Chemistry
JF - Vietnam Journal of Chemistry
ER -