Abstract
A new flavonol, macagigantin A (1), and three known flavonols (2–4) were isolated from Macaranga gigantea leaves. The structure of macagigantin A was fully assigned by 1D and 2D NMR, UV, and highresolution mass spectra data. The cytotoxic activity of 1–4 was evaluated against 4T1, P-388, and HeLa cells. Compound 1 showed potent activity against 4T1 cells with an IC50 value of 1.18 μg/mL, and compound 3 showed moderate activity against P-388 cells (IC50 value of 2.54 μg/mL).
Original language | English |
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Pages (from-to) | 287-290 |
Number of pages | 4 |
Journal | Natural Product Sciences |
Volume | 29 |
Issue number | 4 |
DOIs | |
Publication status | Published - 2023 |
Keywords
- Cytotoxic
- Flavonoid
- Macagigantin A
- Macaranga gigantea