Macagigantin A, A New Flavonoid from Macaranga gigantea (Rchb.f & Zoll.) Mull.Arg

Mulyadi Tanjung, Tjitjik Srie Tjahjandarie, Muhammad Fajar Aldin, Shola Mardhiyyah, Norizan Ahmat, Ratih Dewi Saputri

Research output: Contribution to journalArticlepeer-review


A new flavonol, macagigantin A (1), and three known flavonols (2–4) were isolated from Macaranga gigantea leaves. The structure of macagigantin A was fully assigned by 1D and 2D NMR, UV, and highresolution mass spectra data. The cytotoxic activity of 1–4 was evaluated against 4T1, P-388, and HeLa cells. Compound 1 showed potent activity against 4T1 cells with an IC50 value of 1.18 μg/mL, and compound 3 showed moderate activity against P-388 cells (IC50 value of 2.54 μg/mL).

Original languageEnglish
Pages (from-to)287-290
Number of pages4
JournalNatural Product Sciences
Issue number4
Publication statusPublished - 2023


  • Cytotoxic
  • Flavonoid
  • Macagigantin A
  • Macaranga gigantea


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