Long-term systolic blood pressure variability independent of mean blood pressure is associated with mortality and cardiovascular events: A systematic review and meta-analysis

Pandit Bagus Tri Saputra, Ariikah Dyah Lamara, Mahendra Eko Saputra, Diar Pasahari, Roy Bagus Kurniawan, Makhyan J.Al Farabi, Chaq El Chaq Zamzam Multazam, Yudi Her Oktaviono, Firas F. Alkaff

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)

Abstract

The association between long-term systolic blood pressure variability (SBPV) and cardiovascular (CV) outcomes after being adjusted with mean blood pressure (BP) is questionable. This systematic review aims to evaluate the associations between mean BP adjusted long-term SBPV and CV outcomes. A systematic search was conducted on PubMed, Scopus, and Science Direct on January 4, 2023. A total of 9,944,254 subjects from 43 studies were included in this meta-analysis. Long-term SBPV increased the risk of all-cause mortality (HR 1.21 [95%CI 1.16-1.25], I2=100%), CV mortality (HR 1.10 [95%CI 1.07-11.4], I2 = 90%), MACE (HR 1.10 [1.07-1.13], I2 = 91%), cerebrovascular stroke (HR 1.22 [1.16-1.29], I2=100%), and myocardial infarction (HR 1.13 [95%CI (1.07-1.19)], I2=91%). European populations generally had higher risk compared to other continents. In conclusion, long-term SBPV is associated with all-cause mortality, CV mortality, MACE, MI, and stroke. Poor outcomes related to long-term SBPV seem more dominated by cerebrovascular than coronary events.

Original languageEnglish
Article number102343
JournalCurrent Problems in Cardiology
Volume49
Issue number2
DOIs
Publication statusPublished - Feb 2024

Keywords

  • Major adverse cardiac events
  • Premature mortality
  • Systolic blood pressure variability

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