TY - JOUR
T1 - Long-term systolic blood pressure variability independent of mean blood pressure is associated with mortality and cardiovascular events
T2 - A systematic review and meta-analysis
AU - Saputra, Pandit Bagus Tri
AU - Lamara, Ariikah Dyah
AU - Saputra, Mahendra Eko
AU - Pasahari, Diar
AU - Kurniawan, Roy Bagus
AU - Farabi, Makhyan J.Al
AU - Multazam, Chaq El Chaq Zamzam
AU - Oktaviono, Yudi Her
AU - Alkaff, Firas F.
N1 - Publisher Copyright:
© 2023 The Authors
PY - 2024/2
Y1 - 2024/2
N2 - The association between long-term systolic blood pressure variability (SBPV) and cardiovascular (CV) outcomes after being adjusted with mean blood pressure (BP) is questionable. This systematic review aims to evaluate the associations between mean BP adjusted long-term SBPV and CV outcomes. A systematic search was conducted on PubMed, Scopus, and Science Direct on January 4, 2023. A total of 9,944,254 subjects from 43 studies were included in this meta-analysis. Long-term SBPV increased the risk of all-cause mortality (HR 1.21 [95%CI 1.16-1.25], I2=100%), CV mortality (HR 1.10 [95%CI 1.07-11.4], I2 = 90%), MACE (HR 1.10 [1.07-1.13], I2 = 91%), cerebrovascular stroke (HR 1.22 [1.16-1.29], I2=100%), and myocardial infarction (HR 1.13 [95%CI (1.07-1.19)], I2=91%). European populations generally had higher risk compared to other continents. In conclusion, long-term SBPV is associated with all-cause mortality, CV mortality, MACE, MI, and stroke. Poor outcomes related to long-term SBPV seem more dominated by cerebrovascular than coronary events.
AB - The association between long-term systolic blood pressure variability (SBPV) and cardiovascular (CV) outcomes after being adjusted with mean blood pressure (BP) is questionable. This systematic review aims to evaluate the associations between mean BP adjusted long-term SBPV and CV outcomes. A systematic search was conducted on PubMed, Scopus, and Science Direct on January 4, 2023. A total of 9,944,254 subjects from 43 studies were included in this meta-analysis. Long-term SBPV increased the risk of all-cause mortality (HR 1.21 [95%CI 1.16-1.25], I2=100%), CV mortality (HR 1.10 [95%CI 1.07-11.4], I2 = 90%), MACE (HR 1.10 [1.07-1.13], I2 = 91%), cerebrovascular stroke (HR 1.22 [1.16-1.29], I2=100%), and myocardial infarction (HR 1.13 [95%CI (1.07-1.19)], I2=91%). European populations generally had higher risk compared to other continents. In conclusion, long-term SBPV is associated with all-cause mortality, CV mortality, MACE, MI, and stroke. Poor outcomes related to long-term SBPV seem more dominated by cerebrovascular than coronary events.
KW - Major adverse cardiac events
KW - Premature mortality
KW - Systolic blood pressure variability
UR - http://www.scopus.com/inward/record.url?scp=85182021027&partnerID=8YFLogxK
U2 - 10.1016/j.cpcardiol.2023.102343
DO - 10.1016/j.cpcardiol.2023.102343
M3 - Review article
C2 - 38103812
AN - SCOPUS:85182021027
SN - 0146-2806
VL - 49
JO - Current Problems in Cardiology
JF - Current Problems in Cardiology
IS - 2
M1 - 102343
ER -
