Long-term follow-up results of a multi-institutional phase 2 study of concurrent chemoradiation therapy for locally advanced cervical cancer in east and southeast Asia

Shingo Kato, Tatsuya Ohno, Kullathorn Thephamongkhol, Yaowalak Chansilpa, Jianping Cao, Xiaoting Xu, C. R.Beena Devi, Tang Tieng Swee, Miriam J.C. Calaguas, Rey H. De Los Reyes, Chul Koo Cho, To Anh Dung, Nana Supriana, Dyah Erawati, Hideyuki Mizuno, Takashi Nakano, Hirohiko Tsujii

Research output: Contribution to journalArticlepeer-review

26 Citations (Scopus)

Abstract

Purpose: To report the long-term survival and toxicity of a multi-institutional phase 2 study of concurrent chemoradiation therapy (CCRT) for locally advanced cervical cancer in east and southeast Asia. Methods and Materials: Ten institutions from 8 Asian countries participated in the study. Between April 2003 and March 2006, 120 patients (60 with bulky stage IIB and 60 with stage IIIB) were treated with CCRT. Radiation therapy consisted of pelvic external beam radiation therapy and either high-dose-rate or low-dose-rate intracavitary brachytherapy. Five cycles of weekly cisplatin (40 mg/m 2) were administered during the course of radiation therapy. Treatment results were evaluated by the rates of local control, overall survival, and late toxicities. Results: Median follow-up was 63.7 months, and the follow-up rate at 5 years was 98%. The 5-year local control and overall survival rates for all patients were 76.8% and 55.1%, respectively. The 5-year rates of major late toxicities of the rectum and bladder were 7.9% and 0%, respectively. Conclusions: The long-term results have suggested that CCRT is safe and effective for patients with locally advanced cervical cancer in east and southeast Asia. However, further efforts are needed to improve overall survival.

Original languageEnglish
Pages (from-to)100-105
Number of pages6
JournalInternational Journal of Radiation Oncology Biology Physics
Volume87
Issue number1
DOIs
Publication statusPublished - 1 Sept 2013

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