Lactic acid’s role in hypertonic sodium lactate solution as a neuroprotector measured from the level of ATP, MCT-1, and necrotic areas in intracerebral hematoma rats model

Hamzah, Nancy Margarita Rehatta, Tatang Bisri, Siti Chasnak Saleh, Arie Utariani

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To discover the role of hypertonic sodium lactate (HSL) as the energy source, which in turn will act as a neuroprotector, by measuring adenosine triphosphate (ATP) level, monocarboxylate transporter 1 (MCT-1) and the extent of the necrotic areas. Design: This was an experimental study that used randomized post-test only control group design. Setting: Experimental Animal Care Unit Universitas Gadjah Mada. Patient and participant: 32 white mice of Rattus norvegicus. Intervention: After the protocol of this study was approved by the research ethic committee, _ 32 rats were randomly divided into two groups: HSL group (n=16) and NaCl 3% group (n=16) as the control group. Both groups were anesthetized using conversion-dose pentothal. Results: ATP level in HSL group was higher compared to the control group (p=0.031). MCT-1 in HSL group was also higher than the control group (p=0.010). Necrotic areas were less extensive in the HSL group than the control group (p=0.000). Lactate levels at minute 30 (T30) and minute 360 (T360) increased in the HSL group, while increasing in the control group up to T30, then decreased gradually until T360. Conclusion: Exogenous lactate in solution has effect as a neuroprotective of brain in the intracerebral hemorrhage (ICH).

Original languageEnglish
Pages (from-to)98-108
Number of pages11
JournalCritical Care and Shock
Volume22
Issue number2
Publication statusPublished - 2019

Keywords

  • ATP
  • Extent of necrotic areas
  • Hypertonic sodium lactate
  • Intracerebral hematoma
  • Neuroprotector

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