TY - JOUR
T1 - Kinetical Release Study of Copper Ferrite Nanoparticle Incorporated on PCL/Collagen Nanofiber for Naproxen Delivery
AU - Armedya, Tri Prasetyo
AU - Dzikri, Muhammad Fathan
AU - Sakti, Satya Candra Wibawa
AU - Abdulloh, Abdulloh
AU - Raharjo, Yanuardi
AU - Wafiroh, Siti
AU - Purwati,
AU - Fahmi, Mochamad Zakki
N1 - Funding Information:
Funding Information The authors thank the Ministry of Research, Technology and Higher Education, Republic of Indonesia for the financial support of this research, also Universitas Airlangga for the support on MANDAT research funding.
Funding Information:
The authors thank Universitas Airlangga for the support on facility provided.
Publisher Copyright:
© 2019, Springer Science+Business Media, LLC, part of Springer Nature.
PY - 2019/6/15
Y1 - 2019/6/15
N2 - Nanofiber has become one of tissue engineering examples and has extensive application on medical field, particularly as a wound healing and wound dressing. In this research, nanofiber composite based on polycaprolactone and collagen was successfully obtained via electrospinning process and further developed as host of naproxen as anti-inflammatory agents. Addition of copper ferrite (CuFe2O4) nanoparticles on the nanocomposite becomes an advance part on this study to control of naproxen release. Several characterizations were furnished to prove the design composite nanofiber and its drug release analysis performed to find out the kinetic model and naproxen release mechanism from nanofibers. CuFe2O4 nanoparticles have potential to be used to control naproxen release in nanofiber that lead to decrease level of drug released, where mostly follow the Korsmeyer-Peppas model. The release of naproxen was certainly influenced by pH value, in which the drug was easier to release on base, instead of acid or neutral condition. Varied naproxen and nanoparticle compositions were prepared to reach optimum formulation of the release. This study provides fundamental data for the effect of magnetic nanoparticle on drug release process.
AB - Nanofiber has become one of tissue engineering examples and has extensive application on medical field, particularly as a wound healing and wound dressing. In this research, nanofiber composite based on polycaprolactone and collagen was successfully obtained via electrospinning process and further developed as host of naproxen as anti-inflammatory agents. Addition of copper ferrite (CuFe2O4) nanoparticles on the nanocomposite becomes an advance part on this study to control of naproxen release. Several characterizations were furnished to prove the design composite nanofiber and its drug release analysis performed to find out the kinetic model and naproxen release mechanism from nanofibers. CuFe2O4 nanoparticles have potential to be used to control naproxen release in nanofiber that lead to decrease level of drug released, where mostly follow the Korsmeyer-Peppas model. The release of naproxen was certainly influenced by pH value, in which the drug was easier to release on base, instead of acid or neutral condition. Varied naproxen and nanoparticle compositions were prepared to reach optimum formulation of the release. This study provides fundamental data for the effect of magnetic nanoparticle on drug release process.
KW - Drug delivery system
KW - Kinetic of drug release
KW - Magnetic nanoparticle
KW - Nanofiber
KW - Naproxen
UR - http://www.scopus.com/inward/record.url?scp=85065961236&partnerID=8YFLogxK
U2 - 10.1007/s12668-019-00618-y
DO - 10.1007/s12668-019-00618-y
M3 - Article
AN - SCOPUS:85065961236
VL - 9
SP - 274
EP - 284
JO - BioNanoScience
JF - BioNanoScience
SN - 2191-1630
IS - 2
ER -