TY - JOUR
T1 - Ketoprofen-carboxymethyl chitosan microparticles prepared by spray drying
T2 - Optimization and evaluation
AU - Sari, Retno
AU - Magda, Melatina
AU - Lestari, Wini
AU - Agus Syamsur Rijal, M.
N1 - Publisher Copyright:
© 2015, Asian Journal of Pharmaceutical and Clinical Research. All rights reserved.
PY - 2015
Y1 - 2015
N2 - Objective: The aim of this research was to investigate the effect of two operating parameters (inlet temperature and pump speed) of laboratory spray dryer to optimize the production of ketoprofen-carboxymethyl chitosan (CM chitosan) microparticles and the effect of carboxymethyl chitosan concentration on microparticles characteristics. Methods: Microparticles with various concentration of CM chitosan were prepared by ionic gelation with CaCl2, then dried by spray drying with various inlet temperature and pump speed. The obtained microparticles were evaluation for particle size, drug entrapment efficiency and drug release. Results: The results showed that inlet temperature at 100°C and pump speed at 9.0 ml/min was known to be the optimum condition since the drying process was relatively faster and it could produce the most yield. The obtained CM chitosan microparticles have irregular and hollow shape with the size of 1.1 – 2.1 μm. As carboxymethyl chitosan concentration increased, mean particle size and drug entrapment efficiency of the drugs increased. In simulated intestinal fluid media pH 6.8, the release rate of ketoprofen from microparticles was delayed up to 0.43 times slower than ketoprofen powder. Conclusion: The optimal condition for spray drying in this study was at pump speed 9.0 ml/min with inlet temperature 100°C, since it gave the most yield compare to other conditions. The size of ketoprofen-CM chitosan microparticles were between the range of 1.1 – 2.1 μm with high drug entrapment. In general, microparticles of CM chitosan could delay ketoprofen release in simulated intestinal fluid media.
AB - Objective: The aim of this research was to investigate the effect of two operating parameters (inlet temperature and pump speed) of laboratory spray dryer to optimize the production of ketoprofen-carboxymethyl chitosan (CM chitosan) microparticles and the effect of carboxymethyl chitosan concentration on microparticles characteristics. Methods: Microparticles with various concentration of CM chitosan were prepared by ionic gelation with CaCl2, then dried by spray drying with various inlet temperature and pump speed. The obtained microparticles were evaluation for particle size, drug entrapment efficiency and drug release. Results: The results showed that inlet temperature at 100°C and pump speed at 9.0 ml/min was known to be the optimum condition since the drying process was relatively faster and it could produce the most yield. The obtained CM chitosan microparticles have irregular and hollow shape with the size of 1.1 – 2.1 μm. As carboxymethyl chitosan concentration increased, mean particle size and drug entrapment efficiency of the drugs increased. In simulated intestinal fluid media pH 6.8, the release rate of ketoprofen from microparticles was delayed up to 0.43 times slower than ketoprofen powder. Conclusion: The optimal condition for spray drying in this study was at pump speed 9.0 ml/min with inlet temperature 100°C, since it gave the most yield compare to other conditions. The size of ketoprofen-CM chitosan microparticles were between the range of 1.1 – 2.1 μm with high drug entrapment. In general, microparticles of CM chitosan could delay ketoprofen release in simulated intestinal fluid media.
KW - Carboxymethyl chitosan
KW - Ketoprofen
KW - Microparticles
KW - Spray drying
UR - http://www.scopus.com/inward/record.url?scp=84922564159&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:84922564159
SN - 0974-2441
VL - 8
SP - 331
EP - 333
JO - Asian Journal of Pharmaceutical and Clinical Research
JF - Asian Journal of Pharmaceutical and Clinical Research
IS - 1
ER -