@inproceedings{ad34b465521f474f8463ce0d28aca3fd,
title = "Isolation, transformation, anticancer, and apoptosis activity of lupeyl acetate from Artocarpus integra",
abstract = "Lupeyl acetate-A major constituent of the bark of Artocarpus integra-was isolated and then transformed chemically into lupeol and lupenone by hydrolysis and oxidation reaction respectively. The molecular structures of the prepared compounds were determined based on FTIR, MS and NMR spectrum evidences. Their anticancer activities were determined against breast cancer cells MCF-7 using neutral red assay, while their apoptotic activity were confirmed by flowcytometric analysis using Annexin V-FTIC assay and DNA fragmentation. The IC50 of Lupeyl acetate, lupeol, and lupenone were 48.79; 43.09; and 8.07?μg/mL respectively. The results of flowcytometric analysis and DNA fragmentation showed that anticancer activity of the prepared compounds following apoptosis mechanism.",
keywords = "anticancer, apoptosis., lupenone, lupeol, lupeyl acetate",
author = "Hery Suwito and Heffen, {Wan Lelly} and Herry Cahyana and Suwarso, {Wahyudi Priyono}",
note = "Publisher Copyright: {\textcopyright} 2016 AIP Publishing LLC.; 5th International Conference and Workshop on Basic and Applied Sciences, ICOWOBAS 2015 ; Conference date: 16-10-2015 Through 17-10-2015",
year = "2016",
month = mar,
day = "15",
doi = "10.1063/1.4943339",
language = "English",
series = "AIP Conference Proceedings",
publisher = "American Institute of Physics Inc.",
editor = "Moh. Yasin and Harun, {Sulaiman W.}",
booktitle = "5th International Conference and Workshop on Basic and Applied Sciences, ICOWOBAS 2015",
}
