TY - JOUR
T1 - Isolation of Lignans from The Stem Bark of Willughbeia coriacea and Their Cytotoxic Activity
AU - Harsono, Andre
AU - Rahman, Abror
AU - Putri, Rizqidhana J.
AU - Tjahjandarie, Tjitjik S.
AU - Saputri, Ratih D.
AU - Ahmat, Norizan
AU - Tanjung, Mulyadi
N1 - Funding Information:
The research funded by the Ministry of Education, Culture, Research, and Technology, and Higher, the Republic of Indonesia through Penelitian Dasar, Universitas Airlangga, 2019, No. 720/UN3.14/PT/2019.
Publisher Copyright:
© 2023 Harsono et al.
PY - 2023/2/28
Y1 - 2023/2/28
N2 - Willughbeia coricea Wall is a herbal medicine to treat diarrhea in Dayak People, Kalimantan, Indonesia. This study aims to determine the structure of the lignans and their anticancer activity against cervical cancer cells (HeLa). Two lignan derivatives, (+)-pinoresinol (1) and alyterinate A (2), were isolated from the roots of the W. coricea Wall. The structures of 1 and 2 were determined based on UV, IR, HRESIMS, 1D (1H and13C), and 2D NMR (HMQC and HMBC) spectroscopic analysis. Compounds 1-2 showed moderate activity against HeLa cells with an IC50 value of 10.1 and 12.5 μM, respectively.
AB - Willughbeia coricea Wall is a herbal medicine to treat diarrhea in Dayak People, Kalimantan, Indonesia. This study aims to determine the structure of the lignans and their anticancer activity against cervical cancer cells (HeLa). Two lignan derivatives, (+)-pinoresinol (1) and alyterinate A (2), were isolated from the roots of the W. coricea Wall. The structures of 1 and 2 were determined based on UV, IR, HRESIMS, 1D (1H and13C), and 2D NMR (HMQC and HMBC) spectroscopic analysis. Compounds 1-2 showed moderate activity against HeLa cells with an IC50 value of 10.1 and 12.5 μM, respectively.
KW - (+)-pinoresinol
KW - HeLa cells
KW - Willughbeia coriacea
KW - alyterinate A
KW - lignan
UR - http://www.scopus.com/inward/record.url?scp=85149931100&partnerID=8YFLogxK
U2 - 10.26538/tjnpr/v7i2.14
DO - 10.26538/tjnpr/v7i2.14
M3 - Article
AN - SCOPUS:85149931100
SN - 2616-0684
VL - 7
SP - 2394
EP - 2396
JO - Tropical Journal of Natural Product Research
JF - Tropical Journal of Natural Product Research
IS - 2
ER -
