Isolation of cytotoxic sesquiterpenes from Curcuma comosa and characterization of their structures

Khun Nay Win Tun; Nanik Siti Aminah; Alfinda Novi Kristanti; Rico Ramadhan; Yoshiaki Takaya; Hnin Thanda Aung

Isolation of cytotoxic sesquiterpenes from Curcuma comosa and characterization of their structures

Khun Nay Win Tun, Nanik Siti Aminah, Alfinda Novi Kristanti, Rico Ramadhan, Yoshiaki Takaya, Hnin Thanda Aung

Research output: Contribution to journal › Article › peer-review

Abstract

Three quaiane-type sesquiterpenes named curcumenol (1), zedoarondiol (2), and (1S,4S,5S,10R)-isozedoarondiol (3) were isolated from the rhizomes of Curcuma comosa. Their structures were elucidated on the basis of extensive spectroscopic analysis. The cytotoxic activities of all isolated compounds were tested by MTT assay. Compounds 2 and 3 showed the most potent activities against T47D cell line with IC₅₀ values 12.13 and 10.93 μg/mL, respectively.

Original language	English
Pages (from-to)	1513-1517
Number of pages	5
Journal	Journal of the Indian Chemical Society
Volume	96
Issue number	12
Publication status	Published - Dec 2019

Keywords

Curcuma comosa
MTT assay
Quaiane-type sesquiterpenes
Zingiberaceae

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title = "Isolation of cytotoxic sesquiterpenes from Curcuma comosa and characterization of their structures",

abstract = "Three quaiane-type sesquiterpenes named curcumenol (1), zedoarondiol (2), and (1S,4S,5S,10R)-isozedoarondiol (3) were isolated from the rhizomes of Curcuma comosa. Their structures were elucidated on the basis of extensive spectroscopic analysis. The cytotoxic activities of all isolated compounds were tested by MTT assay. Compounds 2 and 3 showed the most potent activities against T47D cell line with IC50 values 12.13 and 10.93 μg/mL, respectively.",

keywords = "Curcuma comosa, MTT assay, Quaiane-type sesquiterpenes, Zingiberaceae",

author = "{Win Tun}, {Khun Nay} and Aminah, {Nanik Siti} and Kristanti, {Alfinda Novi} and Rico Ramadhan and Yoshiaki Takaya and Aung, {Hnin Thanda}",

year = "2019",

month = dec,

language = "English",

volume = "96",

pages = "1513--1517",

journal = "Journal of the Indian Chemical Society",

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T1 - Isolation of cytotoxic sesquiterpenes from Curcuma comosa and characterization of their structures

AU - Win Tun, Khun Nay

AU - Aminah, Nanik Siti

AU - Kristanti, Alfinda Novi

AU - Ramadhan, Rico

AU - Takaya, Yoshiaki

AU - Aung, Hnin Thanda

PY - 2019/12

Y1 - 2019/12

N2 - Three quaiane-type sesquiterpenes named curcumenol (1), zedoarondiol (2), and (1S,4S,5S,10R)-isozedoarondiol (3) were isolated from the rhizomes of Curcuma comosa. Their structures were elucidated on the basis of extensive spectroscopic analysis. The cytotoxic activities of all isolated compounds were tested by MTT assay. Compounds 2 and 3 showed the most potent activities against T47D cell line with IC50 values 12.13 and 10.93 μg/mL, respectively.

AB - Three quaiane-type sesquiterpenes named curcumenol (1), zedoarondiol (2), and (1S,4S,5S,10R)-isozedoarondiol (3) were isolated from the rhizomes of Curcuma comosa. Their structures were elucidated on the basis of extensive spectroscopic analysis. The cytotoxic activities of all isolated compounds were tested by MTT assay. Compounds 2 and 3 showed the most potent activities against T47D cell line with IC50 values 12.13 and 10.93 μg/mL, respectively.

KW - Curcuma comosa

KW - MTT assay

KW - Quaiane-type sesquiterpenes

KW - Zingiberaceae

UR - http://www.scopus.com/inward/record.url?scp=85081201997&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:85081201997

SN - 0019-4522

VL - 96

SP - 1513

EP - 1517

JO - Journal of the Indian Chemical Society

JF - Journal of the Indian Chemical Society

IS - 12

ER -

Isolation of cytotoxic sesquiterpenes from Curcuma comosa and characterization of their structures

Abstract

Keywords

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