TY - JOUR
T1 - Investigation of compounds and biological activity of selected Indonesian marine sponges
AU - Sahidin, I.
AU - Sabandar, Carla W.
AU - Wahyuni,
AU - Hamsidi, Rini
AU - Mardikasari, Sandra Aulia
AU - Zubaydah, Wa Ode Sitti
AU - Sadarun, Baru
AU - Musnina, Wa Ode Sitti
AU - Darmawan, Ahmad
AU - Sundowo, Andini
N1 - Publisher Copyright:
© 2020 Bentham Science Publishers.
PY - 2020
Y1 - 2020
N2 - Background: Marine sponges provided a great source of natural products with promising biological activity. This study was aimed to investigate the chemical constituents of methanol extracts of selected Indonesian marine sponges (Callyspongia sp., Clathria sp., Melophlus sarasi-norum, and Xestospongia sp.), collected from the Saponda Islands, Southeast Sulawesi, Indonesia as well as to evaluate their antimicrobial and antioxidant activities. Methods: LCMS/MS analysis used to identify the compounds. Agar well diffusion and DPPH assays were used to evaluate the antimicrobial and antioxidant activities. Results: Chemical screening reported alkaloids, terpenoids, steroids, and saponins from all investigated sponges. The LC-MS/MS analysis identified various compounds which mainly contained ster-oids. Antimicrobial activity (against Bacillus subtilis, Escherichia coli, Salmonella enterica, and Candida albicans) was only shown by the Xestospongia sp. extract. Meanwhile, extracts of M. sarasinorum, Xestospongia sp., and Callyspongia sp. exhibited potent radical scavenging activity. Conclusion: The study concluded that the selected sponges could provide various groups of compounds. Methanol extracts of these sponges could be used as sources of antimicrobial and antioxidant agents.
AB - Background: Marine sponges provided a great source of natural products with promising biological activity. This study was aimed to investigate the chemical constituents of methanol extracts of selected Indonesian marine sponges (Callyspongia sp., Clathria sp., Melophlus sarasi-norum, and Xestospongia sp.), collected from the Saponda Islands, Southeast Sulawesi, Indonesia as well as to evaluate their antimicrobial and antioxidant activities. Methods: LCMS/MS analysis used to identify the compounds. Agar well diffusion and DPPH assays were used to evaluate the antimicrobial and antioxidant activities. Results: Chemical screening reported alkaloids, terpenoids, steroids, and saponins from all investigated sponges. The LC-MS/MS analysis identified various compounds which mainly contained ster-oids. Antimicrobial activity (against Bacillus subtilis, Escherichia coli, Salmonella enterica, and Candida albicans) was only shown by the Xestospongia sp. extract. Meanwhile, extracts of M. sarasinorum, Xestospongia sp., and Callyspongia sp. exhibited potent radical scavenging activity. Conclusion: The study concluded that the selected sponges could provide various groups of compounds. Methanol extracts of these sponges could be used as sources of antimicrobial and antioxidant agents.
KW - Antimicrobial
KW - Antioxidant
KW - Chemical constituents
KW - LC-MS analysis
KW - Marine sponge
KW - Methanol
UR - http://www.scopus.com/inward/record.url?scp=85085619929&partnerID=8YFLogxK
U2 - 10.2174/2210315509666190627105237
DO - 10.2174/2210315509666190627105237
M3 - Article
AN - SCOPUS:85085619929
SN - 2210-3155
VL - 10
SP - 312
EP - 321
JO - Natural Products Journal
JF - Natural Products Journal
IS - 3
ER -