TY - JOUR
T1 - Injectable bone substitute of hydroxyapatite-gelatin composite with alendronate for bone defect due to osteoporosis
AU - Putra, Alfian Pramudita
AU - Hikmawati, Dyah
AU - Budiatin, Aniek Setiya
N1 - Publisher Copyright:
© 2019 Journal of International Dental and Medical Research.
PY - 2019
Y1 - 2019
N2 - World Health Organization mentioned that there were 200 million people in the world suffered from osteoporosis in 2013 and half of them has bone fractures. Hydroxyapatite as a bioactive material was explored as a substitute for bone defect or osteoporosis. The conventional bone filler was lack of the ability to let the filler to fill the irregular defect due to osteoporosis. Thus, a new method was introduced called an injectable bone substitute. While the bone filler performs its function to stabilize the mechanical property of the defected bone, the addition of a drug, such as an alendronate, would be beneficial. The injectable bone substitute (IBS) based on hydroxyapatite-gelatin was synthesized with the addition of alendronate. The Fourier Transform Infrared (FTIR) result showed a bond formation of hydroxyapatite and gelatin by shifting of carboxyl group wavenumber from 1332,72 cm-1 to 1559-1543 cm from gelatin with Ca2+ from hydroxyapatite. The IBS viscosity was (38.7±0.53) dPa.s and was able to be extruded from the syringe. The IBS could become suspension again after sedimentation and did not change the pH of SBF solution. The IBS was precipitated with a suitable substrate. The cytotoxicity test showed that the samples were non-toxic. The results of IBS characterizations demonstrated that it has potential to be used as a bone filler as well as drug delivery system to the bone defect due to osteoporosis.
AB - World Health Organization mentioned that there were 200 million people in the world suffered from osteoporosis in 2013 and half of them has bone fractures. Hydroxyapatite as a bioactive material was explored as a substitute for bone defect or osteoporosis. The conventional bone filler was lack of the ability to let the filler to fill the irregular defect due to osteoporosis. Thus, a new method was introduced called an injectable bone substitute. While the bone filler performs its function to stabilize the mechanical property of the defected bone, the addition of a drug, such as an alendronate, would be beneficial. The injectable bone substitute (IBS) based on hydroxyapatite-gelatin was synthesized with the addition of alendronate. The Fourier Transform Infrared (FTIR) result showed a bond formation of hydroxyapatite and gelatin by shifting of carboxyl group wavenumber from 1332,72 cm-1 to 1559-1543 cm from gelatin with Ca2+ from hydroxyapatite. The IBS viscosity was (38.7±0.53) dPa.s and was able to be extruded from the syringe. The IBS could become suspension again after sedimentation and did not change the pH of SBF solution. The IBS was precipitated with a suitable substrate. The cytotoxicity test showed that the samples were non-toxic. The results of IBS characterizations demonstrated that it has potential to be used as a bone filler as well as drug delivery system to the bone defect due to osteoporosis.
KW - Alendronate
KW - Bone defect
KW - Hydroxyapatite-gelatin composite
KW - Injectable bone substitute
KW - Osteoporosis
UR - http://www.scopus.com/inward/record.url?scp=85069519252&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:85069519252
SN - 1309-100X
VL - 12
SP - 813
EP - 818
JO - Journal of International Dental and Medical Research
JF - Journal of International Dental and Medical Research
IS - 2
ER -