Inhibitory effect of mucoadhesive gingival patch of mangosteen peel extract against periodonto pathogen bacteria

Rini Devijanti Ridwan, Tuti Kusumaningsih, Thea Devina, Denny Saputra

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Chronic periodontitis is inflammation of periodontal tissue that develops slowly, mainly caused by Porphyromonas gingivalis and Fusobacterium nucleatum. Mangosteen peel extract (Garcinia mangostana) is known to inhibit the growth of anaerobic Gram-negative bacteria so that it can be used as an alternative antimicrobial treatment for chronic periodontitis. Mucoadhesive gingival patch can be used as a topical drug administration through the mucosa and nanoparticles allowing drug ingredients to be delivered more quickly and on target. The purpose of this study is to prove the ability of mucoadhesive gingival patch mangosteen peel extract in inhibiting the growth of bacteria that cause chronic periodontitis. P. gingivalis and F. nucleatum were given gingival patch mucoadhesive mangosteen peel extract, mucoadhesive gingival patch nanoparticle mangosteen peel extract, doxycycline mucoadhesive gingival patch with menthol and without menthol, mucoadhesive gingival patch without extract, and mangosteen peel extract with 4 repetitions at a dose of 100 mg and 200 mg using the well diffusion method. Mangosteen gingival patch of mangosteen peel extract showed significant differences with a gingival patch of mucoadhesive nanoparticle mangosteen peel extract but not significant with mangosteen peel extract. Mucoadhesive gingival patch were not significant with doxycycline mucoadhesive gingival patch with or without menthol in studies of P. gingivalis and F. nucleatum at a dose of 100 mg. Nanoparticles gingival mucoadhesive patch mangosteen peel extract 200 mg against F. nucleatum showed significant differences with mucoadhesive gingival patch of mangosteen peel extract (p = 0.014) and doxycycline mucoadhesive gingival patch with menthol (p = 0) but not significant with mangosteen peel extract (p = 0.064) and doxycycline mucoadhesive gingival patch without menthol (p = 0.934). Mucoadhesive gingival patch mangosteen peel extract can inhibit the growth of bacteria that cause chronic periodontitis namely P. gingivalis and F. nucleatum.

Original languageEnglish
Pages (from-to)843-848
Number of pages6
JournalJournal of International Dental and Medical Research
Volume13
Issue number3
Publication statusPublished - 2020

Keywords

  • Fusobacterium nucleatum
  • Garcinia mangostana
  • Mucoadhesive gingival patch
  • Nanoparticle
  • Porphyromonas gingivalis

Fingerprint

Dive into the research topics of 'Inhibitory effect of mucoadhesive gingival patch of mangosteen peel extract against periodonto pathogen bacteria'. Together they form a unique fingerprint.

Cite this