Inhibitory Activity and Docking Analysis of Antimalarial Agents from Stemona sp. toward Ferredoxin-NADP+ Reductase from Malaria Parasites

Pratiwi Pudjiastuti; Ni Nyoman T. Puspaningsih; Imam Siswanto; Much Z. Fanani; Yoko K. Ariga; Toshiharu Hase; Satyajit D. Sarker; Lutfun Nahar

doi:10.1155/2018/3469132

Inhibitory Activity and Docking Analysis of Antimalarial Agents from Stemona sp. toward Ferredoxin-NADP+ Reductase from Malaria Parasites

Pratiwi Pudjiastuti, Ni Nyoman T. Puspaningsih, Imam Siswanto, Much Z. Fanani, Yoko K. Ariga, Toshiharu Hase, Satyajit D. Sarker, Lutfun Nahar

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

Ferredoxin-NADP⁺ reductases (FNRs, EC 1.18.1.2) were found in the plastids of Plasmodium and have been considered as a target for the development of new antimalarial agents. Croomine, epi-croomine, tuberostemonine, javastemonine A, and isoprotostemonine are isolated alkaloids from the roots of Stemona sp. and their inhibitory effect on FNRs from Plasmodium falciparum (PfFNR) was investigated. Croomine showed the highest level of inhibition (33.9%) of electron transfer from PfFNR to PfFd, while tuberstemonine displayed the highest level of inhibition (55.4%) of diaphorase activity of PfFNR. Docking analysis represented that croomine is located at the middle position of PfFNR and PfFd. Croomine from S. tuberosa appeared to have potential as an antimalarial agent.

Original language	English
Article number	3469132
Journal	Journal of Parasitology Research
Volume	2018
DOIs	https://doi.org/10.1155/2018/3469132
Publication status	Published - 2018

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1155/2018/3469132

Cite this

@article{52e8c874f3b944238ff2d49ee2eea305,

title = "Inhibitory Activity and Docking Analysis of Antimalarial Agents from Stemona sp. toward Ferredoxin-NADP+ Reductase from Malaria Parasites",

abstract = "Ferredoxin-NADP+ reductases (FNRs, EC 1.18.1.2) were found in the plastids of Plasmodium and have been considered as a target for the development of new antimalarial agents. Croomine, epi-croomine, tuberostemonine, javastemonine A, and isoprotostemonine are isolated alkaloids from the roots of Stemona sp. and their inhibitory effect on FNRs from Plasmodium falciparum (PfFNR) was investigated. Croomine showed the highest level of inhibition (33.9%) of electron transfer from PfFNR to PfFd, while tuberstemonine displayed the highest level of inhibition (55.4%) of diaphorase activity of PfFNR. Docking analysis represented that croomine is located at the middle position of PfFNR and PfFd. Croomine from S. tuberosa appeared to have potential as an antimalarial agent.",

author = "Pratiwi Pudjiastuti and Puspaningsih, {Ni Nyoman T.} and Imam Siswanto and Fanani, {Much Z.} and Ariga, {Yoko K.} and Toshiharu Hase and Sarker, {Satyajit D.} and Lutfun Nahar",

note = "Publisher Copyright: {\textcopyright} 2018 Pratiwi Pudjiastuti et al.",

year = "2018",

doi = "10.1155/2018/3469132",

language = "English",

volume = "2018",

journal = "Journal of Parasitology Research",

issn = "2090-0023",

publisher = "John Wiley and Sons Ltd",

}

TY - JOUR

T1 - Inhibitory Activity and Docking Analysis of Antimalarial Agents from Stemona sp. toward Ferredoxin-NADP+ Reductase from Malaria Parasites

AU - Pudjiastuti, Pratiwi

AU - Puspaningsih, Ni Nyoman T.

AU - Siswanto, Imam

AU - Fanani, Much Z.

AU - Ariga, Yoko K.

AU - Hase, Toshiharu

AU - Sarker, Satyajit D.

AU - Nahar, Lutfun

PY - 2018

Y1 - 2018

N2 - Ferredoxin-NADP+ reductases (FNRs, EC 1.18.1.2) were found in the plastids of Plasmodium and have been considered as a target for the development of new antimalarial agents. Croomine, epi-croomine, tuberostemonine, javastemonine A, and isoprotostemonine are isolated alkaloids from the roots of Stemona sp. and their inhibitory effect on FNRs from Plasmodium falciparum (PfFNR) was investigated. Croomine showed the highest level of inhibition (33.9%) of electron transfer from PfFNR to PfFd, while tuberstemonine displayed the highest level of inhibition (55.4%) of diaphorase activity of PfFNR. Docking analysis represented that croomine is located at the middle position of PfFNR and PfFd. Croomine from S. tuberosa appeared to have potential as an antimalarial agent.

AB - Ferredoxin-NADP+ reductases (FNRs, EC 1.18.1.2) were found in the plastids of Plasmodium and have been considered as a target for the development of new antimalarial agents. Croomine, epi-croomine, tuberostemonine, javastemonine A, and isoprotostemonine are isolated alkaloids from the roots of Stemona sp. and their inhibitory effect on FNRs from Plasmodium falciparum (PfFNR) was investigated. Croomine showed the highest level of inhibition (33.9%) of electron transfer from PfFNR to PfFd, while tuberstemonine displayed the highest level of inhibition (55.4%) of diaphorase activity of PfFNR. Docking analysis represented that croomine is located at the middle position of PfFNR and PfFd. Croomine from S. tuberosa appeared to have potential as an antimalarial agent.

UR - http://www.scopus.com/inward/record.url?scp=85053411513&partnerID=8YFLogxK

U2 - 10.1155/2018/3469132

DO - 10.1155/2018/3469132

M3 - Article

AN - SCOPUS:85053411513

SN - 2090-0023

VL - 2018

JO - Journal of Parasitology Research

JF - Journal of Parasitology Research

M1 - 3469132

ER -

Inhibitory Activity and Docking Analysis of Antimalarial Agents from Stemona sp. toward Ferredoxin-NADP+ Reductase from Malaria Parasites

Abstract

UN SDGs

Access to Document

Fingerprint

Cite this