INFLUENZA A(H5N1) VIRUSES FROM PIGS, INDONESIA

Chairul A. Nidom; Ryo Takano; Shinya Yamada; Yuko Sakai-Tagawa; Syafril Daulay; Didi Aswadi; Takashi Suzuki; Yasuo Suzuki; Kyoko Shinya; Kiyoko Iwatsuki-Horimoto; Yukiko Muramoto; Yoshihiro Kawaoka

INFLUENZA A(H5N1) VIRUSES FROM PIGS, INDONESIA

Chairul A. Nidom, Ryo Takano, Shinya Yamada, Yuko Sakai-Tagawa, Syafril Daulay, Didi Aswadi, Takashi Suzuki, Yasuo Suzuki, Kyoko Shinya, Kiyoko Iwatsuki-Horimoto, Yukiko Muramoto, Yoshihiro Kawaoka

Research output: Contribution to journal › Article › peer-review

Abstract

Pigs have long been considered potential intermediate hosts in which avian influenza viruses can adapt to humans. To determine whether this potential exists for pigs in Indonesia, we conducted surveillance during 2005–2009. We found that 52 pigs in 4 provinces were infected during 2005–2007 but not 2008–2009. Phylogenetic analysis showed that the viruses had been introduced into the pig population in Indonesia on at least 3 occasions. One isolate had acquired the ability to recognize a human-type receptor. No infected pig had influenza-like symptoms, indicating that influenza A (H5N1) viruses can replicate undetected for prolonged periods, facilitating avian virus adaptation to mammalian hosts. Our data suggest that pigs are at risk for infection during outbreaks of influenza virus A (H5N1) and can serve as intermediate hosts in which this avian virus can adapt to mammals.

Original language	English
Pages (from-to)	194-202
Number of pages	9
Journal	Romanian Journal of Infectious Diseases
Volume	12
Issue number	4
Publication status	Published - 2009

Keywords

avian influenza viruses
host

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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title = "INFLUENZA A(H5N1) VIRUSES FROM PIGS, INDONESIA",

abstract = "Pigs have long been considered potential intermediate hosts in which avian influenza viruses can adapt to humans. To determine whether this potential exists for pigs in Indonesia, we conducted surveillance during 2005–2009. We found that 52 pigs in 4 provinces were infected during 2005–2007 but not 2008–2009. Phylogenetic analysis showed that the viruses had been introduced into the pig population in Indonesia on at least 3 occasions. One isolate had acquired the ability to recognize a human-type receptor. No infected pig had influenza-like symptoms, indicating that influenza A (H5N1) viruses can replicate undetected for prolonged periods, facilitating avian virus adaptation to mammalian hosts. Our data suggest that pigs are at risk for infection during outbreaks of influenza virus A (H5N1) and can serve as intermediate hosts in which this avian virus can adapt to mammals.",

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author = "Nidom, {Chairul A.} and Ryo Takano and Shinya Yamada and Yuko Sakai-Tagawa and Syafril Daulay and Didi Aswadi and Takashi Suzuki and Yasuo Suzuki and Kyoko Shinya and Kiyoko Iwatsuki-Horimoto and Yukiko Muramoto and Yoshihiro Kawaoka",

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TY - JOUR

T1 - INFLUENZA A(H5N1) VIRUSES FROM PIGS, INDONESIA

AU - Nidom, Chairul A.

AU - Takano, Ryo

AU - Yamada, Shinya

AU - Sakai-Tagawa, Yuko

AU - Daulay, Syafril

AU - Aswadi, Didi

AU - Suzuki, Takashi

AU - Suzuki, Yasuo

AU - Shinya, Kyoko

AU - Iwatsuki-Horimoto, Kiyoko

AU - Muramoto, Yukiko

AU - Kawaoka, Yoshihiro

PY - 2009

Y1 - 2009

N2 - Pigs have long been considered potential intermediate hosts in which avian influenza viruses can adapt to humans. To determine whether this potential exists for pigs in Indonesia, we conducted surveillance during 2005–2009. We found that 52 pigs in 4 provinces were infected during 2005–2007 but not 2008–2009. Phylogenetic analysis showed that the viruses had been introduced into the pig population in Indonesia on at least 3 occasions. One isolate had acquired the ability to recognize a human-type receptor. No infected pig had influenza-like symptoms, indicating that influenza A (H5N1) viruses can replicate undetected for prolonged periods, facilitating avian virus adaptation to mammalian hosts. Our data suggest that pigs are at risk for infection during outbreaks of influenza virus A (H5N1) and can serve as intermediate hosts in which this avian virus can adapt to mammals.

AB - Pigs have long been considered potential intermediate hosts in which avian influenza viruses can adapt to humans. To determine whether this potential exists for pigs in Indonesia, we conducted surveillance during 2005–2009. We found that 52 pigs in 4 provinces were infected during 2005–2007 but not 2008–2009. Phylogenetic analysis showed that the viruses had been introduced into the pig population in Indonesia on at least 3 occasions. One isolate had acquired the ability to recognize a human-type receptor. No infected pig had influenza-like symptoms, indicating that influenza A (H5N1) viruses can replicate undetected for prolonged periods, facilitating avian virus adaptation to mammalian hosts. Our data suggest that pigs are at risk for infection during outbreaks of influenza virus A (H5N1) and can serve as intermediate hosts in which this avian virus can adapt to mammals.

KW - avian influenza viruses

KW - host

UR - http://www.scopus.com/inward/record.url?scp=85142791623&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:85142791623

SN - 1454-3389

VL - 12

SP - 194

EP - 202

JO - Romanian Journal of Infectious Diseases

JF - Romanian Journal of Infectious Diseases

IS - 4

ER -

INFLUENZA A(H5N1) VIRUSES FROM PIGS, INDONESIA

Abstract

Keywords

UN SDGs

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