Inflammatory markers in response to interval and continuous exercise in obese women

Sakina, Sakina, A. Pranoto, T. W.Aga Seputra, Sugiharto, M. Miftahussurur, M. Miftahussurur, A. Andarianto, P. S. Rejeki, P. S. Rejeki, P. S. Rejeki

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4 Citations (Scopus)


Obesity is strongly associated with the degree of inflammation characterised by proinflammatory cytokines, such as tumour necrosis factor-a (TNF-a). Lifestyle modification with exercise is the right strategy because it can stimulate interleukin 6 (IL-6) secretion which acts as an anti-inflammatory. This study aimed to analyse the response of interval and continuous exercise to inflammatory markers in obese women. Twenty-four women participated in this study and were randomly divided into 3 groups: CONG (n=8, control group without any intervention): MCEG (n=8, continuous exercise group) and MIEG (n=8, interval exercise group). ELISA was used to measure the levels of IL-6 and TNF-a, pre-exercise and post-exercise. The data were analysed using the paired sample t-test. The mean levels of TNF-a, pre-exercise and post-exercise, were 19.35±2.73 vs 19.36±2.23 pg/ml (P =0.989) in CONG, 19.42±2.79 vs 16.63±0.82 pg/ml (P=0.017) in MCEG, and 19.46±3.08 vs 16.96±2.11 pg/ml (P=0.079) in MIEG. Mean levels of IL-6, pre-exercise and post-exercise, were 7.56±2.88 vs 7.66±4.12 pg/ml (P=0.957) for CONG, 7.68±3.41 vs 13.97±2.38 pg/ml (P=0.001) for MCEG, and 7.78±1.99 vs 13.66±3.55 pg/ml (P=0.001) for MIEG. We concluded that interval and continuous exercise decreased pro-inflammatory and increased anti-inflammatory cytokines.

Original languageEnglish
Pages (from-to)135-142
Number of pages8
JournalComparative Exercise Physiology
Issue number2
Publication statusPublished - 2022


  • continuous exercise
  • inflammatory markers
  • interval exercise
  • obese women


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