TY - JOUR
T1 - Inflammatory cytokines affecting cardiovascular function
T2 - a scoping review
AU - Kristanti, Risma Aprianda
AU - Bramantoro, Taufan
AU - Soesilawati, Pratiwi
AU - Hariyani, Ninuk
AU - Suryadinata, Arief
AU - Purwanto, Bambang
AU - Nugraha, Alexander Patera
AU - Tengku Ahmad Noor, Tengku Natasha Eleena binti
N1 - Funding Information:
The author(s) declared that no grants were involved in supporting this work.
Publisher Copyright:
Copyright: © 2022 Kristanti RA et al.
PY - 2022
Y1 - 2022
N2 - Background: A chronic inflammatory process can cause disorders on the cardiovascular system. It is caused by an enhancement of inflammatory cytokines that can decrease the heart working-function. This article aims to review inflammatory cytokines that can cause the cardiovascular system disease. Methods: The review process began by taking articles from two databases, namely PubMed and SpringerLink without using the publication year limit. The reviewed article was a research article using human samples, which analyzed the impact of inflammatory cytokines on cardiovascular disease or the risk level of cardiovascular disease. Result: From a total of 3926 articles originating from two databases, 21 obtained articles have matched with the inclusion criteria for the review process. Of those 21 articles, 17 reported an increased effect of inflammatory cytokines on cardiovascular disease, while four articles showed no association between increased inflammatory cytokines and cardiovascular disease. There were six inflammatory cytokines that could affect cardiovascular disease, namely: TNF-α, IL-1β, IL-2, IL-6, IL-8, and IL-17 where cytokine IL-6 is confirmed by as many as 14 articles, TNF-α as many as six articles, and IL-1 β as many as three articles as inflammatory cytokines that could affect cardiovascular function. Conclusion: The increased level of inflammatory cytokines can be a trigger for decreased function and cause the disease in the cardiovascular system.
AB - Background: A chronic inflammatory process can cause disorders on the cardiovascular system. It is caused by an enhancement of inflammatory cytokines that can decrease the heart working-function. This article aims to review inflammatory cytokines that can cause the cardiovascular system disease. Methods: The review process began by taking articles from two databases, namely PubMed and SpringerLink without using the publication year limit. The reviewed article was a research article using human samples, which analyzed the impact of inflammatory cytokines on cardiovascular disease or the risk level of cardiovascular disease. Result: From a total of 3926 articles originating from two databases, 21 obtained articles have matched with the inclusion criteria for the review process. Of those 21 articles, 17 reported an increased effect of inflammatory cytokines on cardiovascular disease, while four articles showed no association between increased inflammatory cytokines and cardiovascular disease. There were six inflammatory cytokines that could affect cardiovascular disease, namely: TNF-α, IL-1β, IL-2, IL-6, IL-8, and IL-17 where cytokine IL-6 is confirmed by as many as 14 articles, TNF-α as many as six articles, and IL-1 β as many as three articles as inflammatory cytokines that could affect cardiovascular function. Conclusion: The increased level of inflammatory cytokines can be a trigger for decreased function and cause the disease in the cardiovascular system.
KW - cardiovascular disease
KW - dentistry
KW - interleukin 6
KW - medicine
KW - non-communicable disease
KW - tumor necrosis factor-α
UR - http://www.scopus.com/inward/record.url?scp=85152897456&partnerID=8YFLogxK
U2 - 10.12688/f1000research.122390.1
DO - 10.12688/f1000research.122390.1
M3 - Article
AN - SCOPUS:85152897456
SN - 2046-1402
VL - 11
JO - F1000Research
JF - F1000Research
M1 - 1078
ER -