Increased level of TNF-a in serum and peritoneal fluid of endometriosis women-related infertility

N. Y. Rahmawati, F. Ahsan, B. Santoso, A. F. Mufid, A. Sa’adi, S. R. Dwiningsih, A. Tunjungseto, M. Y.A. Widyanugraha

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


Endometriosis is a chronic inflammatory disorder characterized by abnormal endometrial tissue outside the uterine cavity, with a prevalence of 10% worldwide. TNF-a has been implicated in developing endometriosis; however, TNF-a is mainly unexplored in women with infertility cases. We aimed to evaluate serum and the peritoneal fluid level of TNF-a in endometriosis patients and correlate its level to the severity of endometriosis. Peripheral blood and peritoneal fluid samples were obtained from 87 infertility cases that underwent laparoscopy, consisting of 44 endometriosis women and 43 non-endometriosis women. We assessed serum and peritoneal fluid levels of TNF-a using an enzyme-linked immunosorbent assay. Serum and peritoneal fluid TNF-a levels were significantly increased in the endometriosis group compared to the control group (p-value = 0.0278; p-value = 0.0271). Serum and peritoneal TNF-a levels significantly differed between late-endometriosis and the control group (pvalue = 0.026, p-value = 0.004). Our results show increased levels of TNF-a level in endometriosis women related to infertility cases that correlate with the severity of endometriosis.

Original languageEnglish
Title of host publicationImproving Health for Better Future Life
Subtitle of host publicationStrengthening from Basic Science to Clinical Research
PublisherCRC Press
Number of pages8
ISBN (Electronic)9781003860136
ISBN (Print)9781032686356
Publication statusPublished - 1 Jan 2023


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