Increased Hsp-72 Expression in Oral Mucormycosis after treatment with Hyperbaric Oxygen (HBO)

Fanny Margaretha Laihad, I. Ketut Sudiana, M. Guritno S, Sumarno Reto Prawiro, Sunarjo, Retno Indrawati, Theresia Indah Budhy, Herjunianto, Titut Harnanik, Noengki Prameswari, Arya Brahmanta, Eddy Hermanto

Research output: Contribution to journalArticlepeer-review


Mucormycosis is a rare invasive fungal infection, but fatal when it occurs and triggered by tooth extraction. Heat Shock Protein (HSP)-72 allegedly serves to protect the cell from stress. The aim of this study is to analyze the expression of Hsp-72 in maxillary mucosal tissue of mucormycosis infection on dental extraction after Hyperbaric Oxygen (HBO) therapy. 34 male marmots with age of 3-4 month were divided into 6 groups: 1 control group, 1 group of dental extraction and 4 intervention group. Two group, first with injection of Rhizopus oryzae strain CBS 110.17, and then tooh extraction. The other two group, dental extraction first and then rhizopus oryzae injection. The four interventions group were divided with non HBO and HBO treatment of 2,4 ATA 3x30 minute, one session, for 5 days. The expression of HSP-72 was examined by immunohistochemistry. Mean of (K-1): 0,17±0,12; (K-2): 0,62±0,15; (K-3): 0,52±0,19; (K-4): 6,07±2,79; (K-5): 1,18±0,82; and (K-6): 2,92±0,84. K-4 is the most dominant compared to the other group. HBO therapy 2,4 ATA, 3x30’, for 5 days has been significantly proven to increase the expression of Hsp-72 in macrophage of maxillary mucosal which infected by mucormycosis until 35,7 times higher than normal group.

Original languageEnglish
Pages (from-to)633-638
Number of pages6
JournalJournal of International Dental and Medical Research
Issue number2
Publication statusPublished - 29 Jun 2020


  • Hsp
  • hyperbaric oxygen therapy
  • oral mucormycosis
  • tooth extraction


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