The relationship between the increase of CD 34 and TRPV-1 stimulation after being given by I capsaicin in bone defect healing. Twenty-one male wistar rats were disorderly divided into three I categories (each category=7): the first (K0=negative control), the second (K1=positive control), and I the third (K2=treatment). Both K0 and K1 were only given with serotype b Aggregatibacter I actinomycetemcomintas (A.a) to the cervical part of area of the first molar. The K2 category was I given by serotype b A.a and cayenne pepper extract at dose 0.0912 mg/kg/day. After a week, the I rats were sacrified using thionembutal with dose 30 mg/kg in accordance with their weight and for I manufacturing sample specimen from gingival tissue region by immunology testing using I immunohistochemical method. The acquired data were contrasted using a one-way Anova test. I Result confirmed both TRPV-1 compute and CD-34 in K2 category to be prominent divergence in I both TRPV-1 and CD-34 than K1 and K0 (p<0.05), whereas there was no prominent divergence I between K1 and K0 (p>0.05). Capsaisin promotes the number of CD 34, angiogenesis factors, and I microbial agents that it can be confirmed as the alternative treatment for bone defect healing I caused by periodontitis.

Original languageEnglish
Pages (from-to)954-958
Number of pages5
JournalJournal of International Dental and Medical Research
Issue number3
Publication statusPublished - 2021


  • CD 34
  • Capsaisin
  • HSCs
  • Immunology
  • TRPV-1


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