Incidence and mutation analysis of glucose-6-phosphate dehydrogenase deficiency in Eastern Indonesian populations

Indah S. Tantular, Hiroyuki Matsuoka, Yuichi Kasahara, Suhintam Pusarawati, Toshio Kanbe, Josef S.B. Tuda, Yasutoshi Kido, Yoes P. Dachlan, Fumihiko Kawamoto

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8 Citations (Scopus)


We conducted a field survey of glucose-6-phosphate dehydrogenese (G6PD) deficiency in the eastern Indonesian islands, and analyzed G6PD variants molecularly. The incidence of G6PD deficiency in 5 ethnic groups (Manggarai, Bajawa, Nage-Keo, Larantuka, and Palue) on the Flores and Palue Islands was lower than that of another native group, Sikka, or a nonnative group, Riung. Molecular analysis of G6PD variants indicated that 19 cases in Sikka had a frequency distribution of G6PD variants similar to those in our previous studies, while 8 cases in Riung had a different frequency distribution of G6PD variants. On the other hand, from field surveys in another 8 ethnic groups (Timorese, Sumbanese, Savunese, Kendari, Buton, Muna, Minahasa, and Sangirese) on the islands of West Timor, Sumba, Sulawesi, Muna and Bangka, a total of 49 deficient cases were detected. Thirty-nine of these 49 cases had G6PD Vanua Lava (383 T>C) of Melanesian origin. In our previous studies, many cases of G6PD Vanua Lava were found on other eastern Indonesian islands. Taken together, these findings may indicate that G6PD Vanua Lava is the most common variant in eastern Indonesian populations, except for Sikka.

Original languageEnglish
Pages (from-to)367-373
Number of pages7
JournalActa Medica Okayama
Issue number6
Publication statusPublished - Dec 2010


  • Eastern Indonesian population
  • G6PD Vanua Lava
  • Glucose-6-phosphate dehydrogenase deficiency
  • Molecular analysis
  • Rapid G6PD test


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