TY - JOUR
T1 - Incidence and mutation analysis of glucose-6-phosphate dehydrogenase deficiency in Eastern Indonesian populations
AU - Tantular, Indah S.
AU - Matsuoka, Hiroyuki
AU - Kasahara, Yuichi
AU - Pusarawati, Suhintam
AU - Kanbe, Toshio
AU - Tuda, Josef S.B.
AU - Kido, Yasutoshi
AU - Dachlan, Yoes P.
AU - Kawamoto, Fumihiko
PY - 2010/12
Y1 - 2010/12
N2 - We conducted a field survey of glucose-6-phosphate dehydrogenese (G6PD) deficiency in the eastern Indonesian islands, and analyzed G6PD variants molecularly. The incidence of G6PD deficiency in 5 ethnic groups (Manggarai, Bajawa, Nage-Keo, Larantuka, and Palue) on the Flores and Palue Islands was lower than that of another native group, Sikka, or a nonnative group, Riung. Molecular analysis of G6PD variants indicated that 19 cases in Sikka had a frequency distribution of G6PD variants similar to those in our previous studies, while 8 cases in Riung had a different frequency distribution of G6PD variants. On the other hand, from field surveys in another 8 ethnic groups (Timorese, Sumbanese, Savunese, Kendari, Buton, Muna, Minahasa, and Sangirese) on the islands of West Timor, Sumba, Sulawesi, Muna and Bangka, a total of 49 deficient cases were detected. Thirty-nine of these 49 cases had G6PD Vanua Lava (383 T>C) of Melanesian origin. In our previous studies, many cases of G6PD Vanua Lava were found on other eastern Indonesian islands. Taken together, these findings may indicate that G6PD Vanua Lava is the most common variant in eastern Indonesian populations, except for Sikka.
AB - We conducted a field survey of glucose-6-phosphate dehydrogenese (G6PD) deficiency in the eastern Indonesian islands, and analyzed G6PD variants molecularly. The incidence of G6PD deficiency in 5 ethnic groups (Manggarai, Bajawa, Nage-Keo, Larantuka, and Palue) on the Flores and Palue Islands was lower than that of another native group, Sikka, or a nonnative group, Riung. Molecular analysis of G6PD variants indicated that 19 cases in Sikka had a frequency distribution of G6PD variants similar to those in our previous studies, while 8 cases in Riung had a different frequency distribution of G6PD variants. On the other hand, from field surveys in another 8 ethnic groups (Timorese, Sumbanese, Savunese, Kendari, Buton, Muna, Minahasa, and Sangirese) on the islands of West Timor, Sumba, Sulawesi, Muna and Bangka, a total of 49 deficient cases were detected. Thirty-nine of these 49 cases had G6PD Vanua Lava (383 T>C) of Melanesian origin. In our previous studies, many cases of G6PD Vanua Lava were found on other eastern Indonesian islands. Taken together, these findings may indicate that G6PD Vanua Lava is the most common variant in eastern Indonesian populations, except for Sikka.
KW - Eastern Indonesian population
KW - G6PD Vanua Lava
KW - Glucose-6-phosphate dehydrogenase deficiency
KW - Molecular analysis
KW - Rapid G6PD test
UR - http://www.scopus.com/inward/record.url?scp=78650710319&partnerID=8YFLogxK
M3 - Article
C2 - 21173806
AN - SCOPUS:78650710319
SN - 0386-300X
VL - 64
SP - 367
EP - 373
JO - Acta Medica Okayama
JF - Acta Medica Okayama
IS - 6
ER -