TY - JOUR
T1 - In vivo anticancer activity of benzoxazine and aminomethyl compounds derived from eugenol
AU - Rudyanto, Marcellino
AU - Ekowati, Juni
AU - Widiandani, Tri
AU - Syahrani, Achmad
N1 - Funding Information:
This research was funded by Ministry of Research, Technology and Higher Education of The Republic of Indonesia through Penelitian Unggulan Perguruan Tinggi (PUPT) research grant with con-tract number 018/SP2H/LT/DRPM/11/2016. No.
Funding Information:
Conflict of interest: The authors declare no potential conflict of interest. ied the anti-proliferative and pro-apoptotic activity of eugenol-related biphenyls on malignant melanoma cells.6 Sudarma et al. Funding: This research was funded by Ministry of Research, (2009) added sulfonyl and amino groups to the aromatic ring,7 Technology and Higher Education of The Republic of Indonesia through while Hidalgo (2009) studied the antioxidant capacity of eugenol Penelitian Unggulan Perguruan Tinggi (PUPT) research grant with con- derivatives.8
Publisher Copyright:
© the Author(s), 2023.
PY - 2023/3/30
Y1 - 2023/3/30
N2 - Background: Indonesia is the world’s primary producer of clove. In order to find new utilization for clove and new biologi-cally active compounds, eugenol, the main constituent of clove, has been converted to its derivatives. Objective: This study aims to examine in vivo anticancer activity of benzoxazine and aminomethyl compounds derived from eugenol. Methods: Fibrosarcoma was induced by injection of benzo(a)pyrene solution. The test compounds were given per oral at 20, 40, and 80 mg/Kg body weight, once a day for 30 days. Results: As a result, all the tested compounds showed activity in reducing the cancer incidence rate. All the tested compounds were also found to reduce tumor weight. Benzoxazine derivatives gave slightly better activity compared to aminomethyl derivatives. The strongest activity was exhibited by 6-allyl-3-(furan-2-ylmethyl)-8-methoxy-3,4-dihydro-2H-benzo(e)(1,3)oxazine. Conclusions: All four benzoxazine and aminomethyl compounds derived from eugenol that were tested exhibited anticancer activity in mice fibrosarcoma.
AB - Background: Indonesia is the world’s primary producer of clove. In order to find new utilization for clove and new biologi-cally active compounds, eugenol, the main constituent of clove, has been converted to its derivatives. Objective: This study aims to examine in vivo anticancer activity of benzoxazine and aminomethyl compounds derived from eugenol. Methods: Fibrosarcoma was induced by injection of benzo(a)pyrene solution. The test compounds were given per oral at 20, 40, and 80 mg/Kg body weight, once a day for 30 days. Results: As a result, all the tested compounds showed activity in reducing the cancer incidence rate. All the tested compounds were also found to reduce tumor weight. Benzoxazine derivatives gave slightly better activity compared to aminomethyl derivatives. The strongest activity was exhibited by 6-allyl-3-(furan-2-ylmethyl)-8-methoxy-3,4-dihydro-2H-benzo(e)(1,3)oxazine. Conclusions: All four benzoxazine and aminomethyl compounds derived from eugenol that were tested exhibited anticancer activity in mice fibrosarcoma.
KW - Eugenol
KW - aminomethyl
KW - anticancer
KW - benzoxazines
UR - http://www.scopus.com/inward/record.url?scp=85153265353&partnerID=8YFLogxK
U2 - 10.4081/jphia.2023.2511
DO - 10.4081/jphia.2023.2511
M3 - Article
AN - SCOPUS:85153265353
SN - 2038-9922
VL - 14
JO - Journal of Public Health in Africa
JF - Journal of Public Health in Africa
IS - S1
M1 - 2511
ER -
