In vitro test of antituberculosis streptomycin loaded in injectable bone substitute

Inten Firdhausi Wardhani; Dyah Hikmawati; Rofi Mega Rizki Samudra; Katherine

In vitro test of antituberculosis streptomycin loaded in injectable bone substitute

Inten Firdhausi Wardhani, Dyah Hikmawati, Aminatun, Rofi Mega Rizki Samudra, Katherine

Research output: Contribution to journal › Article › peer-review

Abstract

Indonesia was placed as the 3^rd country worldwide in which tuberculosis sufferers were highest. Injectable Bone Substitute (IBS) paste loaded with streptomycin killed the bacteria. It also consisted of hydroxyapatite which was useful for the bone regeneration. This study was aimed at testing the performance of IBS paste in vitro, by using the antituberculosis test and cytotoxicity test using hepatocyte cell. The in vitro study conducted by this study had proven that the streptomycin could be released from IBS paste and killed the bacteria of Mycobacterium tuberculosis, shown by the clear zone of the antituberculosis test. Moreover, the cytotoxicity test resulted in a positive characteristic where IBS paste was not toxic and safe if implanted in human body.

Original language	English
Pages (from-to)	337-341
Number of pages	5
Journal	Annals of Biology
Volume	36
Issue number	2
Publication status	Published - Apr 2020

Keywords

Cytotoxicity
IBS paste
In vitro
Local drug
Spinal tuberculosis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

@article{63b61816959043e88214853e6745db30,

title = "In vitro test of antituberculosis streptomycin loaded in injectable bone substitute",

abstract = "Indonesia was placed as the 3rd country worldwide in which tuberculosis sufferers were highest. Injectable Bone Substitute (IBS) paste loaded with streptomycin killed the bacteria. It also consisted of hydroxyapatite which was useful for the bone regeneration. This study was aimed at testing the performance of IBS paste in vitro, by using the antituberculosis test and cytotoxicity test using hepatocyte cell. The in vitro study conducted by this study had proven that the streptomycin could be released from IBS paste and killed the bacteria of Mycobacterium tuberculosis, shown by the clear zone of the antituberculosis test. Moreover, the cytotoxicity test resulted in a positive characteristic where IBS paste was not toxic and safe if implanted in human body.",

keywords = "Cytotoxicity, IBS paste, In vitro, Local drug, Spinal tuberculosis",

author = "Wardhani, {Inten Firdhausi} and Dyah Hikmawati and Aminatun and Samudra, {Rofi Mega Rizki} and Katherine",

year = "2020",

month = apr,

language = "English",

volume = "36",

pages = "337--341",

journal = "Annals of Biology",

issn = "0970-0153",

publisher = "Agri. Bio. Publishers",

number = "2",

}

TY - JOUR

T1 - In vitro test of antituberculosis streptomycin loaded in injectable bone substitute

AU - Wardhani, Inten Firdhausi

AU - Hikmawati, Dyah

AU - Aminatun,

AU - Samudra, Rofi Mega Rizki

AU - Katherine,

PY - 2020/4

Y1 - 2020/4

N2 - Indonesia was placed as the 3rd country worldwide in which tuberculosis sufferers were highest. Injectable Bone Substitute (IBS) paste loaded with streptomycin killed the bacteria. It also consisted of hydroxyapatite which was useful for the bone regeneration. This study was aimed at testing the performance of IBS paste in vitro, by using the antituberculosis test and cytotoxicity test using hepatocyte cell. The in vitro study conducted by this study had proven that the streptomycin could be released from IBS paste and killed the bacteria of Mycobacterium tuberculosis, shown by the clear zone of the antituberculosis test. Moreover, the cytotoxicity test resulted in a positive characteristic where IBS paste was not toxic and safe if implanted in human body.

AB - Indonesia was placed as the 3rd country worldwide in which tuberculosis sufferers were highest. Injectable Bone Substitute (IBS) paste loaded with streptomycin killed the bacteria. It also consisted of hydroxyapatite which was useful for the bone regeneration. This study was aimed at testing the performance of IBS paste in vitro, by using the antituberculosis test and cytotoxicity test using hepatocyte cell. The in vitro study conducted by this study had proven that the streptomycin could be released from IBS paste and killed the bacteria of Mycobacterium tuberculosis, shown by the clear zone of the antituberculosis test. Moreover, the cytotoxicity test resulted in a positive characteristic where IBS paste was not toxic and safe if implanted in human body.

KW - Cytotoxicity

KW - IBS paste

KW - In vitro

KW - Local drug

KW - Spinal tuberculosis

UR - http://www.scopus.com/inward/record.url?scp=85086154623&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:85086154623

SN - 0970-0153

VL - 36

SP - 337

EP - 341

JO - Annals of Biology

JF - Annals of Biology

IS - 2

ER -

In vitro test of antituberculosis streptomycin loaded in injectable bone substitute

Abstract

Keywords

UN SDGs

Fingerprint

Cite this