In vitro test of antituberculosis streptomycin loaded in injectable bone substitute

Inten Firdhausi Wardhani, Dyah Hikmawati, Aminatun, Rofi Mega Rizki Samudra, Katherine

Research output: Contribution to journalArticlepeer-review


Indonesia was placed as the 3rd country worldwide in which tuberculosis sufferers were highest. Injectable Bone Substitute (IBS) paste loaded with streptomycin killed the bacteria. It also consisted of hydroxyapatite which was useful for the bone regeneration. This study was aimed at testing the performance of IBS paste in vitro, by using the antituberculosis test and cytotoxicity test using hepatocyte cell. The in vitro study conducted by this study had proven that the streptomycin could be released from IBS paste and killed the bacteria of Mycobacterium tuberculosis, shown by the clear zone of the antituberculosis test. Moreover, the cytotoxicity test resulted in a positive characteristic where IBS paste was not toxic and safe if implanted in human body.

Original languageEnglish
Pages (from-to)337-341
Number of pages5
JournalAnnals of Biology
Issue number2
Publication statusPublished - Apr 2020


  • Cytotoxicity
  • IBS paste
  • In vitro
  • Local drug
  • Spinal tuberculosis


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