In vitro study: Effect of cobalt(II) chloride against dengue virus type 1 in Vero cells

Yovilianda Maulitiva Untoro; Teguh Hari Sucipto; Harsasi Setyawati; Anisa Maharani; Novia Faridatus Sholihah; Siti Churrotin; Ilham Harlan Amarullah; Soegeng Soegijanto

doi:10.14499/indonesianjpharm30iss4pp316

In vitro study: Effect of cobalt(II) chloride against dengue virus type 1 in Vero cells

Yovilianda Maulitiva Untoro, Teguh Hari Sucipto, Harsasi Setyawati, Anisa Maharani, Novia Faridatus Sholihah, Siti Churrotin, Ilham Harlan Amarullah, Soegeng Soegijanto

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Dengue virus (DENV) serotypes possess various types from DENV-1 to DENV-4 that are enveloped viruses belong to the genus Flavivirus of the Flaviviridae. Dengue vaccine or antiviral has not yet been clinically approved for humans, even though there have been significant efforts toward this end. Antiviral activity against DENV is needed to develop to be an alternative drug for the DENV virus. Cobalt(II) chloride has been used in the treatment and prevention of diseases of humans since ancient times. This study aimed to investigate the antiviral effects and Cytotoxicity of Cobalt(II) chloride. This compound was further investigated for its inhibitory effect on the replication of DENV-1 in Vero cells. The antiviral activity and cytotoxic was measured by WST-1 assay. The IC50value of the Cobalt(II) chloride for DENV-1 was 0.38 μg/ml. The cytotoxicity of Cobalt(II) chloride to Vero cell suggests that the CC50 value was 2.91 µg/ml. The results of this study demonstrate the anti-dengue serotype 1 inhibitory activity of Cobalt(II) chloride was highly toxic.

Original language	English
Pages (from-to)	316-320
Number of pages	5
Journal	Indonesian Journal of Pharmacy
Volume	30
Issue number	4
DOIs	https://doi.org/10.14499/indonesianjpharm30iss4pp316
Publication status	Published - 2019

Keywords

Antiviral activity
Cobalt(II) chloride
DENV-1

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.14499/indonesianjpharm30iss4pp316

Cite this

@article{67b43f43620a40f391ea341e0be70f1d,

title = "In vitro study: Effect of cobalt(II) chloride against dengue virus type 1 in Vero cells",

abstract = "Dengue virus (DENV) serotypes possess various types from DENV-1 to DENV-4 that are enveloped viruses belong to the genus Flavivirus of the Flaviviridae. Dengue vaccine or antiviral has not yet been clinically approved for humans, even though there have been significant efforts toward this end. Antiviral activity against DENV is needed to develop to be an alternative drug for the DENV virus. Cobalt(II) chloride has been used in the treatment and prevention of diseases of humans since ancient times. This study aimed to investigate the antiviral effects and Cytotoxicity of Cobalt(II) chloride. This compound was further investigated for its inhibitory effect on the replication of DENV-1 in Vero cells. The antiviral activity and cytotoxic was measured by WST-1 assay. The IC50value of the Cobalt(II) chloride for DENV-1 was 0.38 μg/ml. The cytotoxicity of Cobalt(II) chloride to Vero cell suggests that the CC50 value was 2.91 µg/ml. The results of this study demonstrate the anti-dengue serotype 1 inhibitory activity of Cobalt(II) chloride was highly toxic.",

keywords = "Antiviral activity, Cobalt(II) chloride, DENV-1",

author = "Untoro, {Yovilianda Maulitiva} and Sucipto, {Teguh Hari} and Harsasi Setyawati and Anisa Maharani and Sholihah, {Novia Faridatus} and Siti Churrotin and Amarullah, {Ilham Harlan} and Soegeng Soegijanto",

note = "Publisher Copyright: Copyright {\textcopyright} 2019 THE AUTHOR(S). This article is distributed under a Creative Commons Attribution-Share Alike 4.0 International (CC BY-SA 4.0)",

year = "2019",

doi = "10.14499/indonesianjpharm30iss4pp316",

language = "English",

volume = "30",

pages = "316--320",

journal = "Indonesian Journal of Pharmacy",

issn = "2338-9427",

publisher = "Universitas Gadjah Mada - Faculty of Pharmacy",

number = "4",

}

TY - JOUR

T1 - In vitro study

T2 - Effect of cobalt(II) chloride against dengue virus type 1 in Vero cells

AU - Untoro, Yovilianda Maulitiva

AU - Sucipto, Teguh Hari

AU - Setyawati, Harsasi

AU - Maharani, Anisa

AU - Sholihah, Novia Faridatus

AU - Churrotin, Siti

AU - Amarullah, Ilham Harlan

AU - Soegijanto, Soegeng

PY - 2019

Y1 - 2019

N2 - Dengue virus (DENV) serotypes possess various types from DENV-1 to DENV-4 that are enveloped viruses belong to the genus Flavivirus of the Flaviviridae. Dengue vaccine or antiviral has not yet been clinically approved for humans, even though there have been significant efforts toward this end. Antiviral activity against DENV is needed to develop to be an alternative drug for the DENV virus. Cobalt(II) chloride has been used in the treatment and prevention of diseases of humans since ancient times. This study aimed to investigate the antiviral effects and Cytotoxicity of Cobalt(II) chloride. This compound was further investigated for its inhibitory effect on the replication of DENV-1 in Vero cells. The antiviral activity and cytotoxic was measured by WST-1 assay. The IC50value of the Cobalt(II) chloride for DENV-1 was 0.38 μg/ml. The cytotoxicity of Cobalt(II) chloride to Vero cell suggests that the CC50 value was 2.91 µg/ml. The results of this study demonstrate the anti-dengue serotype 1 inhibitory activity of Cobalt(II) chloride was highly toxic.

AB - Dengue virus (DENV) serotypes possess various types from DENV-1 to DENV-4 that are enveloped viruses belong to the genus Flavivirus of the Flaviviridae. Dengue vaccine or antiviral has not yet been clinically approved for humans, even though there have been significant efforts toward this end. Antiviral activity against DENV is needed to develop to be an alternative drug for the DENV virus. Cobalt(II) chloride has been used in the treatment and prevention of diseases of humans since ancient times. This study aimed to investigate the antiviral effects and Cytotoxicity of Cobalt(II) chloride. This compound was further investigated for its inhibitory effect on the replication of DENV-1 in Vero cells. The antiviral activity and cytotoxic was measured by WST-1 assay. The IC50value of the Cobalt(II) chloride for DENV-1 was 0.38 μg/ml. The cytotoxicity of Cobalt(II) chloride to Vero cell suggests that the CC50 value was 2.91 µg/ml. The results of this study demonstrate the anti-dengue serotype 1 inhibitory activity of Cobalt(II) chloride was highly toxic.

KW - Antiviral activity

KW - Cobalt(II) chloride

KW - DENV-1

UR - http://www.scopus.com/inward/record.url?scp=85081567399&partnerID=8YFLogxK

U2 - 10.14499/indonesianjpharm30iss4pp316

DO - 10.14499/indonesianjpharm30iss4pp316

M3 - Article

AN - SCOPUS:85081567399

SN - 2338-9427

VL - 30

SP - 316

EP - 320

JO - Indonesian Journal of Pharmacy

JF - Indonesian Journal of Pharmacy

IS - 4

ER -

In vitro study: Effect of cobalt(II) chloride against dengue virus type 1 in Vero cells

Abstract

Keywords

UN SDGs

Access to Document

Fingerprint

Cite this