In vitro study: Effect of cobalt(II) chloride against dengue virus type 1 in Vero cells

Yovilianda Maulitiva Untoro, Teguh Hari Sucipto, Harsasi Setyawati, Anisa Maharani, Novia Faridatus Sholihah, Siti Churrotin, Ilham Harlan Amarullah, Soegeng Soegijanto

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Dengue virus (DENV) serotypes possess various types from DENV-1 to DENV-4 that are enveloped viruses belong to the genus Flavivirus of the Flaviviridae. Dengue vaccine or antiviral has not yet been clinically approved for humans, even though there have been significant efforts toward this end. Antiviral activity against DENV is needed to develop to be an alternative drug for the DENV virus. Cobalt(II) chloride has been used in the treatment and prevention of diseases of humans since ancient times. This study aimed to investigate the antiviral effects and Cytotoxicity of Cobalt(II) chloride. This compound was further investigated for its inhibitory effect on the replication of DENV-1 in Vero cells. The antiviral activity and cytotoxic was measured by WST-1 assay. The IC50value of the Cobalt(II) chloride for DENV-1 was 0.38 μg/ml. The cytotoxicity of Cobalt(II) chloride to Vero cell suggests that the CC50 value was 2.91 µg/ml. The results of this study demonstrate the anti-dengue serotype 1 inhibitory activity of Cobalt(II) chloride was highly toxic.

Original languageEnglish
Pages (from-to)316-320
Number of pages5
JournalIndonesian Journal of Pharmacy
Issue number4
Publication statusPublished - 2019


  • Antiviral activity
  • Cobalt(II) chloride
  • DENV-1


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