In vitro antiviral activity of pinus merkusii (Pinaceae) stem bark and cone against dengue virus type-2 (denv-2)

Arif Nur Muhammad Ansori, Amaq Fadholly, Annise Proboningrat, Suhailah Hayaza, Raden Joko Kuncoroningrat Susilo, Sin War Naw, Gabrielle Ann Villar Posa, Yuhanis Firza Yusrizal, Mada Triandala Sibero, Teguh Hari Sucipto, Soegeng Soegijanto

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

Dengue is a major mosquito-borne disease that currently has no effective antiviral or vaccine available. Recently, Indonesia is one of the largest countries in the dengue-endemic region, with a total population of more than 250 million. In the present study, the antiviral activity of P. merkusii stem bark and cone were evaluated against dengue virus type-2 (DENV-2; NCBI accession number: KT012509) isolated from Surabaya, Indonesia. We revealed that P. merkusii stem bark and cone inhibited DENV-2 in Vero cells (originally from African green monkey kidney) with IC50= 140.63 μg/mL and 73.78 μg/mL, CC50= 89.65 μg/mL and 249.5 μg/mL, SI= 0.64 and 3.38, respectively. The findings presented here suggest that P. merkusii stem bark and cone exerts potent antiviral activity against DENV-2. Hence, P. merkusii stem bark and cone are potent to inhibit DENV-2 and should be considered for in vivo evaluation in the development of an effective antiviral compound against DENV-2.

Original languageEnglish
Pages (from-to)3706-3709
Number of pages4
JournalResearch Journal of Pharmacy and Technology
Volume14
Issue number7
DOIs
Publication statusPublished - 19 Jul 2021

Keywords

  • Antiviral
  • Dengue
  • Pinus merkusii
  • Vero Cell

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