TY - JOUR
T1 - In vitro antiviral activity of pinus merkusii (Pinaceae) stem bark and cone against dengue virus type-2 (denv-2)
AU - Ansori, Arif Nur Muhammad
AU - Fadholly, Amaq
AU - Proboningrat, Annise
AU - Hayaza, Suhailah
AU - Susilo, Raden Joko Kuncoroningrat
AU - Naw, Sin War
AU - Posa, Gabrielle Ann Villar
AU - Yusrizal, Yuhanis Firza
AU - Sibero, Mada Triandala
AU - Sucipto, Teguh Hari
AU - Soegijanto, Soegeng
N1 - Publisher Copyright:
© RJPT All right reserved.
PY - 2021/7/19
Y1 - 2021/7/19
N2 - Dengue is a major mosquito-borne disease that currently has no effective antiviral or vaccine available. Recently, Indonesia is one of the largest countries in the dengue-endemic region, with a total population of more than 250 million. In the present study, the antiviral activity of P. merkusii stem bark and cone were evaluated against dengue virus type-2 (DENV-2; NCBI accession number: KT012509) isolated from Surabaya, Indonesia. We revealed that P. merkusii stem bark and cone inhibited DENV-2 in Vero cells (originally from African green monkey kidney) with IC50= 140.63 μg/mL and 73.78 μg/mL, CC50= 89.65 μg/mL and 249.5 μg/mL, SI= 0.64 and 3.38, respectively. The findings presented here suggest that P. merkusii stem bark and cone exerts potent antiviral activity against DENV-2. Hence, P. merkusii stem bark and cone are potent to inhibit DENV-2 and should be considered for in vivo evaluation in the development of an effective antiviral compound against DENV-2.
AB - Dengue is a major mosquito-borne disease that currently has no effective antiviral or vaccine available. Recently, Indonesia is one of the largest countries in the dengue-endemic region, with a total population of more than 250 million. In the present study, the antiviral activity of P. merkusii stem bark and cone were evaluated against dengue virus type-2 (DENV-2; NCBI accession number: KT012509) isolated from Surabaya, Indonesia. We revealed that P. merkusii stem bark and cone inhibited DENV-2 in Vero cells (originally from African green monkey kidney) with IC50= 140.63 μg/mL and 73.78 μg/mL, CC50= 89.65 μg/mL and 249.5 μg/mL, SI= 0.64 and 3.38, respectively. The findings presented here suggest that P. merkusii stem bark and cone exerts potent antiviral activity against DENV-2. Hence, P. merkusii stem bark and cone are potent to inhibit DENV-2 and should be considered for in vivo evaluation in the development of an effective antiviral compound against DENV-2.
KW - Antiviral
KW - Dengue
KW - Pinus merkusii
KW - Vero Cell
UR - http://www.scopus.com/inward/record.url?scp=85111440519&partnerID=8YFLogxK
U2 - 10.52711/0974-360X.2021.00641
DO - 10.52711/0974-360X.2021.00641
M3 - Article
AN - SCOPUS:85111440519
SN - 0974-3618
VL - 14
SP - 3706
EP - 3709
JO - Research Journal of Pharmacy and Technology
JF - Research Journal of Pharmacy and Technology
IS - 7
ER -
