In vitro antimalarial activity of chalcone and its derivatives

Melanny Ika Sulistyowaty; Kholis Amalia Nofianti; Tutuk Budiati

In vitro antimalarial activity of chalcone and its derivatives

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Object: to evaluate in vitro antimalarial activity of chalcone and its derivatives. Method: The Chalcones were tested its anti plasmodial activity against Plasmodium falciparum (3D7 strain) by using candle jar method, introduced by Trager and Jensen (1976). Result and Discussion: The tested compounds gave IC₅₀ (half maximal inhibitory concentration) ranged between 0.242 and > 100 μg/ml. Conclusion: All compounds have lower antimalarial activity than commercially standard antimalarial drug, Chloroquine diphosphate.

Original language	English
Pages (from-to)	669-671
Number of pages	3
Journal	International Journal of Pharmacy and Pharmaceutical Sciences
Volume	6
Issue number	1
Publication status	Published - 2014

Keywords

Antimalarial activity
Chalcones
In vitro
Plasmodium falciparum

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Cite this

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abstract = "Object: to evaluate in vitro antimalarial activity of chalcone and its derivatives. Method: The Chalcones were tested its anti plasmodial activity against Plasmodium falciparum (3D7 strain) by using candle jar method, introduced by Trager and Jensen (1976). Result and Discussion: The tested compounds gave IC50 (half maximal inhibitory concentration) ranged between 0.242 and > 100 μg/ml. Conclusion: All compounds have lower antimalarial activity than commercially standard antimalarial drug, Chloroquine diphosphate.",

keywords = "Antimalarial activity, Chalcones, In vitro, Plasmodium falciparum",

author = "Sulistyowaty, \{Melanny Ika\} and Nofianti, \{Kholis Amalia\} and Suzana and Tutuk Budiati",

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T1 - In vitro antimalarial activity of chalcone and its derivatives

AU - Sulistyowaty, Melanny Ika

AU - Nofianti, Kholis Amalia

AU - Suzana,

AU - Budiati, Tutuk

PY - 2014

Y1 - 2014

N2 - Object: to evaluate in vitro antimalarial activity of chalcone and its derivatives. Method: The Chalcones were tested its anti plasmodial activity against Plasmodium falciparum (3D7 strain) by using candle jar method, introduced by Trager and Jensen (1976). Result and Discussion: The tested compounds gave IC50 (half maximal inhibitory concentration) ranged between 0.242 and > 100 μg/ml. Conclusion: All compounds have lower antimalarial activity than commercially standard antimalarial drug, Chloroquine diphosphate.

AB - Object: to evaluate in vitro antimalarial activity of chalcone and its derivatives. Method: The Chalcones were tested its anti plasmodial activity against Plasmodium falciparum (3D7 strain) by using candle jar method, introduced by Trager and Jensen (1976). Result and Discussion: The tested compounds gave IC50 (half maximal inhibitory concentration) ranged between 0.242 and > 100 μg/ml. Conclusion: All compounds have lower antimalarial activity than commercially standard antimalarial drug, Chloroquine diphosphate.

KW - Antimalarial activity

KW - Chalcones

KW - In vitro

KW - Plasmodium falciparum

UR - https://www.scopus.com/pages/publications/84891912671

M3 - Article

AN - SCOPUS:84891912671

SN - 0975-1491

VL - 6

SP - 669

EP - 671

JO - International Journal of Pharmacy and Pharmaceutical Sciences

JF - International Journal of Pharmacy and Pharmaceutical Sciences

IS - 1

ER -

In vitro antimalarial activity of chalcone and its derivatives

Abstract

Keywords

UN SDGs

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