TY - JOUR
T1 - In vitro antimalarial activity of chalcone and its derivatives
AU - Sulistyowaty, Melanny Ika
AU - Nofianti, Kholis Amalia
AU - Suzana,
AU - Budiati, Tutuk
PY - 2014
Y1 - 2014
N2 - Object: to evaluate in vitro antimalarial activity of chalcone and its derivatives. Method: The Chalcones were tested its anti plasmodial activity against Plasmodium falciparum (3D7 strain) by using candle jar method, introduced by Trager and Jensen (1976). Result and Discussion: The tested compounds gave IC50 (half maximal inhibitory concentration) ranged between 0.242 and > 100 μg/ml. Conclusion: All compounds have lower antimalarial activity than commercially standard antimalarial drug, Chloroquine diphosphate.
AB - Object: to evaluate in vitro antimalarial activity of chalcone and its derivatives. Method: The Chalcones were tested its anti plasmodial activity against Plasmodium falciparum (3D7 strain) by using candle jar method, introduced by Trager and Jensen (1976). Result and Discussion: The tested compounds gave IC50 (half maximal inhibitory concentration) ranged between 0.242 and > 100 μg/ml. Conclusion: All compounds have lower antimalarial activity than commercially standard antimalarial drug, Chloroquine diphosphate.
KW - Antimalarial activity
KW - Chalcones
KW - In vitro
KW - Plasmodium falciparum
UR - http://www.scopus.com/inward/record.url?scp=84891912671&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:84891912671
SN - 0975-1491
VL - 6
SP - 669
EP - 671
JO - International Journal of Pharmacy and Pharmaceutical Sciences
JF - International Journal of Pharmacy and Pharmaceutical Sciences
IS - 1
ER -