TY - GEN
T1 - Imprinted zeolite modified carbon paste electrode as a selective potentiometric sensor for blood glucose
AU - Khasanah, Miratul
AU - Widati, Alfa Akustia
AU - Handajani, Usreg Sri
AU - Shofiyyah, Masfah Raudlotus
AU - Rakhma, Sabrina Aulia
AU - Predianto, Herwin
N1 - Publisher Copyright:
© 2020 Author(s).
PY - 2020/6/2
Y1 - 2020/6/2
N2 - Imprinted zeolite modified carbon paste electrode as a potentiometric sensor for glucose analysis in blood serum sample has been developed. In this study, the type of used zeolite was TS-1. Imprinted zeolite (IZ) was synthesized with mole ratio of glucose/Si of 0.0306. The modified electrode prepared by mixing activated carbon, imprinted zeolite, and paraffin granule with mass ratio 9:4:7 from the measurement in range of 10-5 - 10-2 M is with Nernst factor of 28.6 mV/decade, and the detection limit of 4.79 x 10-5 M. The electrode was able to respond the glucose molecules in solution quickly (<30 s), stable for more than 9 weeks (130 times usage) and selective to glucose molecules. The urea, uric acid, and creatine with various concentrations did not interfere to glucose analysis by potentiometry using the electrode. Applying of the electrode for glucose analysis in spiked blood serum samples showed that it had recovery of 91.73±3.48% (n=5), while its accuracy against spectrophotometry method as commonly used method in medical field was 90.58±4.65% (n=5). Based on its performance, potentiometry using the imprinted zeolite modified carbon paste electrode is recommended as an alternative method for routine blood glucose analysis in the medical field.
AB - Imprinted zeolite modified carbon paste electrode as a potentiometric sensor for glucose analysis in blood serum sample has been developed. In this study, the type of used zeolite was TS-1. Imprinted zeolite (IZ) was synthesized with mole ratio of glucose/Si of 0.0306. The modified electrode prepared by mixing activated carbon, imprinted zeolite, and paraffin granule with mass ratio 9:4:7 from the measurement in range of 10-5 - 10-2 M is with Nernst factor of 28.6 mV/decade, and the detection limit of 4.79 x 10-5 M. The electrode was able to respond the glucose molecules in solution quickly (<30 s), stable for more than 9 weeks (130 times usage) and selective to glucose molecules. The urea, uric acid, and creatine with various concentrations did not interfere to glucose analysis by potentiometry using the electrode. Applying of the electrode for glucose analysis in spiked blood serum samples showed that it had recovery of 91.73±3.48% (n=5), while its accuracy against spectrophotometry method as commonly used method in medical field was 90.58±4.65% (n=5). Based on its performance, potentiometry using the imprinted zeolite modified carbon paste electrode is recommended as an alternative method for routine blood glucose analysis in the medical field.
UR - http://www.scopus.com/inward/record.url?scp=85086329002&partnerID=8YFLogxK
U2 - 10.1063/5.0005231
DO - 10.1063/5.0005231
M3 - Conference contribution
AN - SCOPUS:85086329002
T3 - AIP Conference Proceedings
BT - 14th Joint Conference on Chemistry 2019
A2 - Rahmawati, Fitria
A2 - Saraswati, Teguh Endah
A2 - Nugrahaningtyas, Khoirina Dwi
A2 - Marliyana, Soerya Dewi
A2 - Kusumaningsih, Triana
PB - American Institute of Physics Inc.
T2 - 14th Joint Conference on Chemistry 2019, JCC 2019
Y2 - 10 September 2019 through 11 September 2019
ER -