TY - JOUR
T1 - Impact of electric field exposure on p53 and tnf-α in glioblastoma
T2 - An in vivo rat model study
AU - Herjuna, Hana Ranu
AU - Haq, Irwan Barlian Immadoel
AU - Wahyuhadi, Joni
AU - Parenrengi, Muhammad Arifin
AU - Suryaningtyas, Wihasto
AU - Purwati, Purwati
AU - Utomo, Budi
AU - Taruno, Warsito Purwo
N1 - Publisher Copyright:
© 2025 by SPC (Sami Publishing Company).
PY - 2025/2
Y1 - 2025/2
N2 - Glioblastoma is a primary malignant brain tumor with a high recurrence rate and poor prognosis. TNF-α and p53 play significant roles in glioblastoma formation. This experimental in vivo study used a post-test-only control group design to investigate the effects of Electro Capacitive Cancer Treatment (ECCT) on TNF-α and p53 expression in glioblastoma. Glioblastoma cell lines were exposed to ECCT at intensities of 30-50 Vpp and a frequency of 100 kHz for 24 and 72 hours. Results showed that varying ECCT intensity did not affect TNF-α and p53 expression. However, low-intensity electrostatic exposure reduced TNF-α levels compared to the control group, while p53 expression remained unchanged.
AB - Glioblastoma is a primary malignant brain tumor with a high recurrence rate and poor prognosis. TNF-α and p53 play significant roles in glioblastoma formation. This experimental in vivo study used a post-test-only control group design to investigate the effects of Electro Capacitive Cancer Treatment (ECCT) on TNF-α and p53 expression in glioblastoma. Glioblastoma cell lines were exposed to ECCT at intensities of 30-50 Vpp and a frequency of 100 kHz for 24 and 72 hours. Results showed that varying ECCT intensity did not affect TNF-α and p53 expression. However, low-intensity electrostatic exposure reduced TNF-α levels compared to the control group, while p53 expression remained unchanged.
KW - Glioblastoma
KW - In Vivo
KW - P53
KW - TNF-Α
KW - electric fields
UR - http://www.scopus.com/inward/record.url?scp=85202525163&partnerID=8YFLogxK
U2 - 10.48309/jmpcr.2025.460234.1274
DO - 10.48309/jmpcr.2025.460234.1274
M3 - Article
AN - SCOPUS:85202525163
SN - 2981-0221
VL - 7
SP - 215
EP - 222
JO - Journal of Medicinal and Pharmaceutical Chemistry Research
JF - Journal of Medicinal and Pharmaceutical Chemistry Research
IS - 2
ER -
