TY - JOUR
T1 - Immunomodulatory and antioxidant activities of phyllanthus niruri l. Extract against the laying hens infected by Escherichia coli
AU - Sabdoningrum, Emy Koestanti
AU - Hidanah, Sri
AU - Ansori, Arif N.M.
AU - Fadholly, Amaq
N1 - Publisher Copyright:
© RJPT All right reserved.
PY - 2020/5
Y1 - 2020/5
N2 - The purpose of this study was to determine the Phyllanthus niruri L. extract (PNE) as an immunomodulator and antioxidant in laying hens infected by Escherichia coli. This study used completely randomized design (CRD) with 20 chickens divided into six groups consisting of one negative control group given Na-CMC (P0-), positive control group given E. coli (P0+), and three test groups given the PNE 10% (P1), 20% (P2), and 30% (P3). Each test group was given a sample suspension orally by giving once a day for six consecutive days. At the age of 21 weeks E. coli was infected with concentration of 10 6 CFU/mL/body weight. After a week of the E. coli infection, PNE was given with various dosage for 4 weeks. We revealed the data of leukocytes, lymphocytes, SOD and MDA. The data were analyzed by analysis of variance and Duncan test. Interestingly, we showed that PNE at a dose of 10% can increase immune system and antioxidant activity. In sum, we conclude that PNE can increase immune system and antioxidant activity in laying hens infected with E. coli.
AB - The purpose of this study was to determine the Phyllanthus niruri L. extract (PNE) as an immunomodulator and antioxidant in laying hens infected by Escherichia coli. This study used completely randomized design (CRD) with 20 chickens divided into six groups consisting of one negative control group given Na-CMC (P0-), positive control group given E. coli (P0+), and three test groups given the PNE 10% (P1), 20% (P2), and 30% (P3). Each test group was given a sample suspension orally by giving once a day for six consecutive days. At the age of 21 weeks E. coli was infected with concentration of 10 6 CFU/mL/body weight. After a week of the E. coli infection, PNE was given with various dosage for 4 weeks. We revealed the data of leukocytes, lymphocytes, SOD and MDA. The data were analyzed by analysis of variance and Duncan test. Interestingly, we showed that PNE at a dose of 10% can increase immune system and antioxidant activity. In sum, we conclude that PNE can increase immune system and antioxidant activity in laying hens infected with E. coli.
KW - Antioxidant
KW - Escherichia coli
KW - Immunomodulation
KW - Laying hen
KW - Phyllanthus niruri L
UR - http://www.scopus.com/inward/record.url?scp=85087727326&partnerID=8YFLogxK
U2 - 10.5958/0974-360X.2020.00404.7
DO - 10.5958/0974-360X.2020.00404.7
M3 - Article
AN - SCOPUS:85087727326
SN - 0974-3618
VL - 13
SP - 2246
EP - 2250
JO - Research Journal of Pharmacy and Technology
JF - Research Journal of Pharmacy and Technology
IS - 5
ER -