Immunomodulatory and antioxidant activities of phyllanthus niruri l. Extract against the laying hens infected by Escherichia coli

Emy Koestanti Sabdoningrum, Sri Hidanah, Arif N.M. Ansori, Amaq Fadholly

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)

Abstract

The purpose of this study was to determine the Phyllanthus niruri L. extract (PNE) as an immunomodulator and antioxidant in laying hens infected by Escherichia coli. This study used completely randomized design (CRD) with 20 chickens divided into six groups consisting of one negative control group given Na-CMC (P0-), positive control group given E. coli (P0+), and three test groups given the PNE 10% (P1), 20% (P2), and 30% (P3). Each test group was given a sample suspension orally by giving once a day for six consecutive days. At the age of 21 weeks E. coli was infected with concentration of 10 6 CFU/mL/body weight. After a week of the E. coli infection, PNE was given with various dosage for 4 weeks. We revealed the data of leukocytes, lymphocytes, SOD and MDA. The data were analyzed by analysis of variance and Duncan test. Interestingly, we showed that PNE at a dose of 10% can increase immune system and antioxidant activity. In sum, we conclude that PNE can increase immune system and antioxidant activity in laying hens infected with E. coli.

Original languageEnglish
Pages (from-to)2246-2250
Number of pages5
JournalResearch Journal of Pharmacy and Technology
Volume13
Issue number5
DOIs
Publication statusPublished - May 2020

Keywords

  • Antioxidant
  • Escherichia coli
  • Immunomodulation
  • Laying hen
  • Phyllanthus niruri L

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