Immunomodulatory Activity of Black Jinten Oil (Nigella sativa) as Macrophage Activator for Salmonella typimurium Infected Rat

This study was aimed to prove immunomodulatory activity of Nigella sativa as macrophage activator for S.typimurium infected rats. 125 rats were divided into five groups and observed for five days (2^nd, 4^th, 6^th, 8^th, 10^th). The rats were infected with S.typimurium 10⁵CFU by intraperitoneal route, and given black jinten oil doses 12.60 mg, 18.90 mg, 25.20mg/200 gram bw/day, for 10 days. The observation: total number of leukocytes, neutrophils, eosinophils, basophils, lymphocytes, monocytes, activated macrophages. The results showed that black jinten oil was able to maintain an immune response towards normal total number of leukocytes and activated macrophages, in rats which were infected with S.typhimurium.