TY - JOUR
T1 - Immune Profile (Th1, Th2, Th17, T-reg) of Maternal-Paediatrics Population in Leprosy Endemic Areas in East Java, Indonesia
T2 - A Cross-Sectional Study
AU - Prakoeswa, Flora
AU - Prakoeswa, Anisha Calista
AU - Prakoeswa, Camilla Amanda
AU - Listiawan, Muhammad Yulianto
AU - Endaryanto, Anang
AU - Prakoeswa, Cita Rosita Sigit
N1 - Publisher Copyright:
Copyright (c) 2022: Author(s). Published by Advanced Research Publications.
PY - 2022
Y1 - 2022
N2 - Background: Leprosy is one of the neglected tropical infectious diseases in developing countries caused by Mycobacterium leprae. Various morbidity and stigma associated with leprosy infection which affects women more than men have led to its late diagnosis and treatment. Gender status, the role of a person in the household, and parenting are some of the factors that greatly influence the transmission of Mycobacterium leprae to children. This increase in the number of cases will also affect the number of new cases of leprosy in children. Aim: To analyse the immune profile in the maternal-children population in leprosy endemic areas in East Java, Indonesia. Method: We investigated the activities of four subsets of T cells, Th1, Th2, Th17, and Treg by measuring the circulated cytokines (IFN-γ for Th1, IL-4 for Th2, IL-17 for Th17) or marker levels (FOXP3+ for Treg) by using ELISA. Results: The comparison analysis of this study showed a significant difference in FOXP3+ level of maternal leprosy compared with a healthy maternal population and IL-17 level of children leprosy compared with a healthy children population. A negative correlation was found between maternal FOXP3+ levels and children IL-17 levels. Conclusion: The immune profile of the maternal-paediatrics population could be beneficial in planning an intervention to eradicate leprosy.
AB - Background: Leprosy is one of the neglected tropical infectious diseases in developing countries caused by Mycobacterium leprae. Various morbidity and stigma associated with leprosy infection which affects women more than men have led to its late diagnosis and treatment. Gender status, the role of a person in the household, and parenting are some of the factors that greatly influence the transmission of Mycobacterium leprae to children. This increase in the number of cases will also affect the number of new cases of leprosy in children. Aim: To analyse the immune profile in the maternal-children population in leprosy endemic areas in East Java, Indonesia. Method: We investigated the activities of four subsets of T cells, Th1, Th2, Th17, and Treg by measuring the circulated cytokines (IFN-γ for Th1, IL-4 for Th2, IL-17 for Th17) or marker levels (FOXP3+ for Treg) by using ELISA. Results: The comparison analysis of this study showed a significant difference in FOXP3+ level of maternal leprosy compared with a healthy maternal population and IL-17 level of children leprosy compared with a healthy children population. A negative correlation was found between maternal FOXP3+ levels and children IL-17 levels. Conclusion: The immune profile of the maternal-paediatrics population could be beneficial in planning an intervention to eradicate leprosy.
KW - Endemic
KW - Immune
KW - Leprosy
KW - Maternal
KW - Paediatric
UR - https://www.scopus.com/pages/publications/85137732428
U2 - 10.24321/0019.5138.202242
DO - 10.24321/0019.5138.202242
M3 - Article
AN - SCOPUS:85137732428
SN - 0019-5138
VL - 54
SP - 10
EP - 14
JO - Journal of Communicable Diseases
JF - Journal of Communicable Diseases
IS - 1
ER -
