TY - JOUR
T1 - Hypertension and COVID-19
T2 - Potential use of beta-blockers and a call for randomized evidence
AU - Alsagaff, Mochamad Yusuf
AU - Mulia, Eka Prasetya Budi
N1 - Publisher Copyright:
© 2021 Cardiological Society of India
PY - 2021/11/1
Y1 - 2021/11/1
N2 - Hypertension is one of the most common morbidities in COVID-19. Previous studies demonstrated that hypertension increases composite poor outcomes in patients with COVID-19. Beta-blockers is widely used as one of the most common antihypertensive agents. Beta-blockers may hold potential benefits in COVID-19 treatment, with current evidence of the potential mechanism of beta-blockers remains scarce. However, several mechanisms were suggested, including decreasing RAAS pathway activity and lowering the ACE2 levels, reducing cytokine storms, and may be beneficial in reducing mortality in ARDS related COVID-19. Further large-scale randomized clinical trials should be conducted before a definite recommendation can be drawn.
AB - Hypertension is one of the most common morbidities in COVID-19. Previous studies demonstrated that hypertension increases composite poor outcomes in patients with COVID-19. Beta-blockers is widely used as one of the most common antihypertensive agents. Beta-blockers may hold potential benefits in COVID-19 treatment, with current evidence of the potential mechanism of beta-blockers remains scarce. However, several mechanisms were suggested, including decreasing RAAS pathway activity and lowering the ACE2 levels, reducing cytokine storms, and may be beneficial in reducing mortality in ARDS related COVID-19. Further large-scale randomized clinical trials should be conducted before a definite recommendation can be drawn.
KW - ACE2
KW - Adrenergic
KW - Beta-blocker
KW - COVID-19
KW - Hypertension
UR - http://www.scopus.com/inward/record.url?scp=85118565438&partnerID=8YFLogxK
U2 - 10.1016/j.ihj.2021.10.011
DO - 10.1016/j.ihj.2021.10.011
M3 - Article
C2 - 34717930
AN - SCOPUS:85118565438
SN - 0019-4832
VL - 73
SP - 757
EP - 759
JO - Indian Heart Journal
JF - Indian Heart Journal
IS - 6
ER -