TY - GEN
T1 - Hydroxyapatite-gelatin-HPMC composite as injectable bone substitute with alendronate variation for osteoporotic bone
AU - Sari, Novita
AU - Putra, Alfian Pramudita
AU - Siswanto,
AU - Pradipta, Muhammad Fajar Faliasthiunus
AU - Hikmawati, Dyah
N1 - Publisher Copyright:
© 2020 Author(s).
PY - 2020/12/9
Y1 - 2020/12/9
N2 - The treatment of bone with osteoporosis could be done by filling the bone defect with Injectable Bone Substitute (IBS). IBS could be functioned as drug delivery system by associating a drug inside the IBS, such as alendronate for osteoporosis case. In this study, IBS has been synthesized and characterized with the alendronate variations. The IBS was synthesized by stirring hydroxyapatite and gelatin 5% (w/v) with a ratio of 45:55. The alendronate was added to the solution with composition of 0%, 5%, 10%, 15% and 20%. The mixture was mixed with 2% (w/v) HPMC. FTIR test results indicated the formation of hydroxyapatite-gelatin bonding (Ca2+-COO-) at wavenumber of 1560.54 cm-1. The acidity test result indicated that the sample had a pH of 7 and was able to remain stable. The IBS could be set in 3 hours and 38 minutes when injected to HA substrate and capable of enveloping the surface of HA substrate. The pore size of the substrate decreased from range of 153 to 625.8 μm into 247.4 to 480.8 μm. The XRD test results indicated that degree of crystallinity decreased from 76.81% to 75.13%. The best alendronate composition in IBS was 10% compared to the mass of hydroxyapatite.
AB - The treatment of bone with osteoporosis could be done by filling the bone defect with Injectable Bone Substitute (IBS). IBS could be functioned as drug delivery system by associating a drug inside the IBS, such as alendronate for osteoporosis case. In this study, IBS has been synthesized and characterized with the alendronate variations. The IBS was synthesized by stirring hydroxyapatite and gelatin 5% (w/v) with a ratio of 45:55. The alendronate was added to the solution with composition of 0%, 5%, 10%, 15% and 20%. The mixture was mixed with 2% (w/v) HPMC. FTIR test results indicated the formation of hydroxyapatite-gelatin bonding (Ca2+-COO-) at wavenumber of 1560.54 cm-1. The acidity test result indicated that the sample had a pH of 7 and was able to remain stable. The IBS could be set in 3 hours and 38 minutes when injected to HA substrate and capable of enveloping the surface of HA substrate. The pore size of the substrate decreased from range of 153 to 625.8 μm into 247.4 to 480.8 μm. The XRD test results indicated that degree of crystallinity decreased from 76.81% to 75.13%. The best alendronate composition in IBS was 10% compared to the mass of hydroxyapatite.
UR - http://www.scopus.com/inward/record.url?scp=85097990783&partnerID=8YFLogxK
U2 - 10.1063/5.0034044
DO - 10.1063/5.0034044
M3 - Conference contribution
AN - SCOPUS:85097990783
T3 - AIP Conference Proceedings
BT - 2nd International Conference on Physical Instrumentation and Advanced Materials 2019
A2 - Trilaksana, Herri
A2 - Harun, Sulaiman Wadi
A2 - Shearer, Cameron
A2 - Yasin, Moh
PB - American Institute of Physics Inc.
T2 - 2nd International Conference on Physical Instrumentation and Advanced Materials, ICPIAM 2019
Y2 - 22 October 2019
ER -