Hydrogel Scaffold in Pulp Dentin Complex Regeneration

Pulp dentin complex regeneration can be initiated by hydrogel scaffold application in the pulp using tissue engineering concept and it gives many advantages. Excavation in deep dental caries, dental trauma, and iatrogenic reasons are several causes of dental pulp exposure that can affect the pulp vitality. It is crucial to maintain the pulp vitality because it can support the tooth survival by avoiding endodontic treatment which affect the resistance of tooth structure. Pulp vitality can be preserved by inducing pulp regeneration using appropriate material. New approach in endodontic regeneration is using tissue engineering concept with hydrogel scaffold, stem cells and growth factors mechanism. Hydrogel scaffold as three-dimensional media can provide cell homing process in pulp dentin complex and may support adhesion of stem cells to differentiate and initiate growth factors release. Based on several studies, hydrogel scaffold can be formulated to support dental pulp regeneration using tissue engineering concept. Many favorable conditions can be achieved such as acts as delivery drug factor with easy injectable application in tooth and it has a lot of potential in dental pulp tissue regeneration treatment.