TY - JOUR
T1 - Human umbilical cord mesenchymal stem cells induction in peri-implantitis Rattus norvegicus accelerates and enhances osteogenesis activity and implant osseointegration
AU - Hendrijantini, Nike
AU - Kuntjoro, Mefina
AU - Agustono, Bambang
AU - Maya Sitalaksmi, Ratri
AU - Dimas Aditya Ari, Muhammad
AU - Theodora, Marcella
AU - Effendi, Rudy
AU - Setiawan Djuarsa, Ivan
AU - Widjaja, Jennifer
AU - Sosiawan, Agung
AU - Hong, Guang
N1 - Publisher Copyright:
© 2023 The Authors
PY - 2023/2
Y1 - 2023/2
N2 - Background: Peri-implantitis additional treatment generally aims to repair damaged tissue through a regenerative approach. Human umbilical cord mesenchymal stem cells (hUCMSCs) produce a high osteogenic effect and are capable of modulating the immune system by suppressing inflammatory response, modulating bone resorption, and inducing endogenous osteogenesis. Aim: This study was intended to discover the effect of hUCMSCs on an implant osseointegration process in peri-implantitis rat subjects as assessed by several markers including interleukin-10 (IL-10), transforming growth factor-β (TGF-β), receptor activator of nuclear factor kappa- β ligand (RANKL), bone morphogenic protein (BMP-2), osterix (Osx), and osteoprotegerin (OPG). Material and methods: The research design implemented during this study represented a true experimental design incorporating the use of Rattus norvegicus (Wistar strain) as subjects. Results: Data analysed by means of a Brown Forsythe test indicated differences between the increase in BMP-2 expression (p < 0.000) and Osx expression (p < 0.001) and between RANKL expression (p < 0.001, Tukey HSD) and OPG expression (p < 0.000, Games Howell). Conclusion: According to the findings of this research, hUCMSCs induction is successful in accelerating and enhancing osteogenic activity and implant osseointegration in peri-implantitis rat subjects.
AB - Background: Peri-implantitis additional treatment generally aims to repair damaged tissue through a regenerative approach. Human umbilical cord mesenchymal stem cells (hUCMSCs) produce a high osteogenic effect and are capable of modulating the immune system by suppressing inflammatory response, modulating bone resorption, and inducing endogenous osteogenesis. Aim: This study was intended to discover the effect of hUCMSCs on an implant osseointegration process in peri-implantitis rat subjects as assessed by several markers including interleukin-10 (IL-10), transforming growth factor-β (TGF-β), receptor activator of nuclear factor kappa- β ligand (RANKL), bone morphogenic protein (BMP-2), osterix (Osx), and osteoprotegerin (OPG). Material and methods: The research design implemented during this study represented a true experimental design incorporating the use of Rattus norvegicus (Wistar strain) as subjects. Results: Data analysed by means of a Brown Forsythe test indicated differences between the increase in BMP-2 expression (p < 0.000) and Osx expression (p < 0.001) and between RANKL expression (p < 0.001, Tukey HSD) and OPG expression (p < 0.000, Games Howell). Conclusion: According to the findings of this research, hUCMSCs induction is successful in accelerating and enhancing osteogenic activity and implant osseointegration in peri-implantitis rat subjects.
KW - Human umbilical cord mesenchymal stem cells
KW - Implant
KW - Medicine
KW - Osseointegration
KW - Peri-implantitis
UR - http://www.scopus.com/inward/record.url?scp=85146901147&partnerID=8YFLogxK
U2 - 10.1016/j.sdentj.2023.01.003
DO - 10.1016/j.sdentj.2023.01.003
M3 - Article
AN - SCOPUS:85146901147
SN - 1013-9052
VL - 35
SP - 147
EP - 153
JO - Saudi Dental Journal
JF - Saudi Dental Journal
IS - 2
ER -