Human umbilical cord mesenchymal stem cells induction in peri-implantitis Rattus norvegicus accelerates and enhances osteogenesis activity and implant osseointegration

Nike Hendrijantini, Mefina Kuntjoro, Bambang Agustono, Ratri Maya Sitalaksmi, Muhammad Dimas Aditya Ari, Marcella Theodora, Rudy Effendi, Ivan Setiawan Djuarsa, Jennifer Widjaja, Agung Sosiawan, Guang Hong

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Background: Peri-implantitis additional treatment generally aims to repair damaged tissue through a regenerative approach. Human umbilical cord mesenchymal stem cells (hUCMSCs) produce a high osteogenic effect and are capable of modulating the immune system by suppressing inflammatory response, modulating bone resorption, and inducing endogenous osteogenesis. Aim: This study was intended to discover the effect of hUCMSCs on an implant osseointegration process in peri-implantitis rat subjects as assessed by several markers including interleukin-10 (IL-10), transforming growth factor-β (TGF-β), receptor activator of nuclear factor kappa- β ligand (RANKL), bone morphogenic protein (BMP-2), osterix (Osx), and osteoprotegerin (OPG). Material and methods: The research design implemented during this study represented a true experimental design incorporating the use of Rattus norvegicus (Wistar strain) as subjects. Results: Data analysed by means of a Brown Forsythe test indicated differences between the increase in BMP-2 expression (p < 0.000) and Osx expression (p < 0.001) and between RANKL expression (p < 0.001, Tukey HSD) and OPG expression (p < 0.000, Games Howell). Conclusion: According to the findings of this research, hUCMSCs induction is successful in accelerating and enhancing osteogenic activity and implant osseointegration in peri-implantitis rat subjects.

Original languageEnglish
Pages (from-to)147-153
Number of pages7
JournalSaudi Dental Journal
Volume35
Issue number2
DOIs
Publication statusPublished - Feb 2023

Keywords

  • Human umbilical cord mesenchymal stem cells
  • Implant
  • Medicine
  • Osseointegration
  • Peri-implantitis

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