Honey-derived phytochemicals: Implications for stem cell activation and health benefits

Endogenous stem cell (ESC) exploration refers to an increase in the number of stem cells residing in the human body. This can be achieved by administering natural substances, such as honey, which can activate stem cells. Numerous studies have explored the potential of honey for animal and human health, including its antibacterial, antifungal, antiparasitic, anti-inflammatory, immunomodulatory, antioxidant, anti-osteoporosis, anti-malnutrition, and anti-fertility properties. Here, we review the scientific data on the importance of honey as a potential natural substance, and how its ability to activate endogenous stem cells can lead to new therapeutic strategies for different diseases. Honey majorly contributes to stem cell proliferation and differentiation and consequently tissue repair via mobilization and homing of endogenous stem cells toward damaged tissues. Altogether, bioactive compounds in honey or phytochemicals are potential compounds for enhancing stem cell therapeutics for several degenerative diseases.