HLA-DRB1 allele distribution among children with rheumatic heart disease in Haji Adam Malik Hospital Medan, Indonesia

Tina Christina Lumban Tobing; Teddy Ontoseno; Sri Endah Rahayuningsih; Ratna Akbari Ganie; Yahwardiah Siregar

doi:10.17392/1101-20

HLA-DRB1 allele distribution among children with rheumatic heart disease in Haji Adam Malik Hospital Medan, Indonesia

Tina Christina Lumban Tobing, Teddy Ontoseno, Sri Endah Rahayuningsih, Ratna Akbari Ganie, Yahwardiah Siregar

Research output: Contribution to journal › Article › peer-review

Abstract

Rheumatic heart disease (RHD) is influenced by genetic factor, microorganism’s virulence, and environmental factor. The aim of this study was to determine human leukocyte (HLA)-DRB1 allele among children with RHD in Medan, Indonesia. Methods An observational study was conducted at the Department of Child Health, Haji Adam Malik Hospital Medan from April to June 2017. Inclusion criteria were children aged 5-18 years diagnosed with RHD. Children with concomitant congenital heart disease were excluded. HLA-DRB1 alleles were analyzed using the PCR sequence-specific priming (SSP) technique. Statistical analysis was done using computer software. Results A total of 62 children were enrolled. The mean age of children was 12.6 (SD 3.44) years; 33 (53.2%) were male. The most dominant allele was HLA-DRB1*12, followed by HLA-DRB1*15. Conclusion It is proven in this research that RHD is influenced by genetic factor with HLA-DRB1*12 allele found to be the most common allele in children with RHD in Medan, Indonesia.

Original language	English
Pages (from-to)	106-109
Number of pages	4
Journal	Medicinski Glasnik
Volume	17
Issue number	1
DOIs	https://doi.org/10.17392/1101-20
Publication status	Published - Feb 2020

Keywords

Cardiology
Human leukocyte antigen
Paediatric
RHD

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.17392/1101-20

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title = "HLA-DRB1 allele distribution among children with rheumatic heart disease in Haji Adam Malik Hospital Medan, Indonesia",

abstract = "Rheumatic heart disease (RHD) is influenced by genetic factor, microorganism{\textquoteright}s virulence, and environmental factor. The aim of this study was to determine human leukocyte (HLA)-DRB1 allele among children with RHD in Medan, Indonesia. Methods An observational study was conducted at the Department of Child Health, Haji Adam Malik Hospital Medan from April to June 2017. Inclusion criteria were children aged 5-18 years diagnosed with RHD. Children with concomitant congenital heart disease were excluded. HLA-DRB1 alleles were analyzed using the PCR sequence-specific priming (SSP) technique. Statistical analysis was done using computer software. Results A total of 62 children were enrolled. The mean age of children was 12.6 (SD 3.44) years; 33 (53.2%) were male. The most dominant allele was HLA-DRB1*12, followed by HLA-DRB1*15. Conclusion It is proven in this research that RHD is influenced by genetic factor with HLA-DRB1*12 allele found to be the most common allele in children with RHD in Medan, Indonesia.",

keywords = "Cardiology, Human leukocyte antigen, Paediatric, RHD",

author = "Tobing, {Tina Christina Lumban} and Teddy Ontoseno and Rahayuningsih, {Sri Endah} and Ganie, {Ratna Akbari} and Yahwardiah Siregar",

year = "2020",

month = feb,

doi = "10.17392/1101-20",

language = "English",

volume = "17",

pages = "106--109",

journal = "Medicinski Glasnik",

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publisher = "Medical Association of Zenica Doboj Canton",

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}

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T1 - HLA-DRB1 allele distribution among children with rheumatic heart disease in Haji Adam Malik Hospital Medan, Indonesia

AU - Tobing, Tina Christina Lumban

AU - Ontoseno, Teddy

AU - Rahayuningsih, Sri Endah

AU - Ganie, Ratna Akbari

AU - Siregar, Yahwardiah

PY - 2020/2

Y1 - 2020/2

N2 - Rheumatic heart disease (RHD) is influenced by genetic factor, microorganism’s virulence, and environmental factor. The aim of this study was to determine human leukocyte (HLA)-DRB1 allele among children with RHD in Medan, Indonesia. Methods An observational study was conducted at the Department of Child Health, Haji Adam Malik Hospital Medan from April to June 2017. Inclusion criteria were children aged 5-18 years diagnosed with RHD. Children with concomitant congenital heart disease were excluded. HLA-DRB1 alleles were analyzed using the PCR sequence-specific priming (SSP) technique. Statistical analysis was done using computer software. Results A total of 62 children were enrolled. The mean age of children was 12.6 (SD 3.44) years; 33 (53.2%) were male. The most dominant allele was HLA-DRB1*12, followed by HLA-DRB1*15. Conclusion It is proven in this research that RHD is influenced by genetic factor with HLA-DRB1*12 allele found to be the most common allele in children with RHD in Medan, Indonesia.

AB - Rheumatic heart disease (RHD) is influenced by genetic factor, microorganism’s virulence, and environmental factor. The aim of this study was to determine human leukocyte (HLA)-DRB1 allele among children with RHD in Medan, Indonesia. Methods An observational study was conducted at the Department of Child Health, Haji Adam Malik Hospital Medan from April to June 2017. Inclusion criteria were children aged 5-18 years diagnosed with RHD. Children with concomitant congenital heart disease were excluded. HLA-DRB1 alleles were analyzed using the PCR sequence-specific priming (SSP) technique. Statistical analysis was done using computer software. Results A total of 62 children were enrolled. The mean age of children was 12.6 (SD 3.44) years; 33 (53.2%) were male. The most dominant allele was HLA-DRB1*12, followed by HLA-DRB1*15. Conclusion It is proven in this research that RHD is influenced by genetic factor with HLA-DRB1*12 allele found to be the most common allele in children with RHD in Medan, Indonesia.

KW - Cardiology

KW - Human leukocyte antigen

KW - Paediatric

KW - RHD

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SN - 1840-0132

VL - 17

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JO - Medicinski Glasnik

JF - Medicinski Glasnik

IS - 1

ER -

HLA-DRB1 allele distribution among children with rheumatic heart disease in Haji Adam Malik Hospital Medan, Indonesia

Abstract

Keywords

UN SDGs

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