Cadmium is a toxic chemical element which causes disruption inorgans. The liver is the main target organ of Cadmium toxicity. The damage caused by oxidative stress which causes lipid peroxidation. Lipid peroxidation made changes in the cells that lead to the death of the cells. This study aims to evaluate histopathologic changes in liver tissue. Mice were divided into 4 groups consisting 5 mice per group, with total20 mice. T0 as anegative control group, T1 as the positive control group which injected by Cadmium 4, 5mg/kgBW, T2 as the group that given Curcumin therapy 150mg/kgBW and T3 as the group that given Curcumin therapy 300mg/kgBW. All treatment was given ten days consecutively. Day 17 all mice were sacrificed for histopathological examination. The data was analyzed using Kruskal Wallis then followed by Mann Whitney U test. It showed that T1 group has the highest histopathological changes among groups 8,80 ± 1,643; p< 0.01 then followed by T2 group 6, 60 ± 1, 517; p< 0.01. T1 as the negative control group showed slightest number of histopathological changes with 1, 40 ± 0, 894; p< 0.01 and followed by T3 1, 60±1, 140; p<0.01. Result showed that the number of histopathological changes is decreased in T3 group with 300mg/kgBW dose. The conclusion is Curcumin can improve the quality of liver histopathology which intoxicated by Cadmium.