TY - JOUR
T1 - Histomorphological studies of the organs of malaria mice model after administration combination of leaf and stem bark extract of syzygium cumini with chloroquine
AU - Maslachah, Lilik
AU - Suwanti, Lucia Tri
AU - Primarizky, Hardany
AU - Widiyatno, Thomas V.
AU - Kusuma, Dyah Fitria Ratna
AU - Winanda, Ridhofajuri
AU - Prasetyo, Ryandika Wahyu
N1 - Publisher Copyright:
© 2020, Institute of Medico-Legal Publications. All rights reserved.
PY - 2020/10/1
Y1 - 2020/10/1
N2 - This study aims to assess the histomorphological finding of the in spleen, brain, kidneys and lungs organ in malaria mice model after administration combination of Leaf and Stem bark extract of Syzygium cumini with chloroquine. Thirty-five male albino mice were randomly assigned into 7 treatment groups. K0: not infected, K1: infected. K2: infected+chloroquine. P1: infected+Syzygium cumini leaf extract. P2: infected+chloroquine+Syzygium cumini leaf extract. P3: infected +Syzygium cumini stem bark extract. P4: infected +chloroquine+ Syzygium cumini stem bark extract. Therapy was given once a day for 4 days after 24 hours post infection. The 21stday, mice were euthanasia. The organs were taken in order to make histopathology preparations, stained with hematoxylin and eosin. The combination of Syzygium cumini leaf extract and chloroquine in mice infected with P. berghei can reduce cerebrum and cerebellum microglia cell counts, white pulp diameter size, haemorrhages damage, alveolar congestion, edema and thickened alveolar septa of lung, decreased tubular necrosis, and interstitial nephritis of renal.
AB - This study aims to assess the histomorphological finding of the in spleen, brain, kidneys and lungs organ in malaria mice model after administration combination of Leaf and Stem bark extract of Syzygium cumini with chloroquine. Thirty-five male albino mice were randomly assigned into 7 treatment groups. K0: not infected, K1: infected. K2: infected+chloroquine. P1: infected+Syzygium cumini leaf extract. P2: infected+chloroquine+Syzygium cumini leaf extract. P3: infected +Syzygium cumini stem bark extract. P4: infected +chloroquine+ Syzygium cumini stem bark extract. Therapy was given once a day for 4 days after 24 hours post infection. The 21stday, mice were euthanasia. The organs were taken in order to make histopathology preparations, stained with hematoxylin and eosin. The combination of Syzygium cumini leaf extract and chloroquine in mice infected with P. berghei can reduce cerebrum and cerebellum microglia cell counts, white pulp diameter size, haemorrhages damage, alveolar congestion, edema and thickened alveolar septa of lung, decreased tubular necrosis, and interstitial nephritis of renal.
KW - Chloroquine
KW - Histomorphological
KW - Mice
KW - P. berghei
KW - Syzygium cumini
UR - http://www.scopus.com/inward/record.url?scp=85099392557&partnerID=8YFLogxK
U2 - 10.37506/ijfmt.v14i4.12057
DO - 10.37506/ijfmt.v14i4.12057
M3 - Article
AN - SCOPUS:85099392557
SN - 0973-9122
VL - 14
SP - 3068
EP - 3075
JO - Indian Journal of Forensic Medicine and Toxicology
JF - Indian Journal of Forensic Medicine and Toxicology
IS - 4
ER -