High rates of hepatitis B virus (HBV),hepatitis C virus (HCV),and human immunodeficiency virus infections and uncommon HBV genotype/subtype and HCV subtype distributions among transgender individuals in Surabaya,Indonesia

Alfonsus Adrian Hadikusumo, Takako Utsumi, Mochamad Amin, Siti Qamariyah Khairunisa, Anittaqwa Istimagfirah, Rury Mega Wahyuni, Maria Inge Lusida, Soetjipto, Edhi Rianto, Juniastuti, Yoshitake Hayashi

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

Transgender people are at a high risk for sexually transmitted viruses such as hepatitis B virus (HBV) and human immunodeficiency virus (HIV). Moreover,Indonesia has a moderate-to-high rate of HBV infection and rapid epidemic growth of HIV infection; hepatitis C virus (HCV) infection can co-occur with HBV and HIV infections. In this study,10 of 107 individuals (9.3z) were positive for HBV surface antigen (HBsAg) and/or HBV DNA,whereas 19 of 101 individuals (18.8z) with negative results for HBsAg were positive for HBV core antibody (anti-HBc). Seven of the 107 individuals (6.5z) were anti-HCV positive,and 16 of the 100 tested samples (16.0z) were HIV positive. Genotype and subtype analyses of all 10 HBV DNA (6 HBsAg positive and 4 anti-HBc positive) strains showed that 3 were of the HBV genotype/HBsAg subtype C/adrq+,one was of C/adw2,and 5 were of B/adw2. The HCV subtype distribution showed that 33.3z were of HCV-1b,and 66.7z were of HCV-3k (n = 6). These distributions differed from those found in the general population of Surabaya,Indonesia. Interestingly,HIV subtype analysis showed a high prevalence of HIV,with possible recombinants of CRF01_AE and subtype B.

Original languageEnglish
Pages (from-to)493-499
Number of pages7
JournalJapanese Journal of Infectious Diseases
Volume69
Issue number6
DOIs
Publication statusPublished - 2016

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