TY - JOUR
T1 - Hepatoprotective Effect of Gamma-mangostin for Amelioration of Impaired Liver Structure and Function in Streptozotocin-induced Diabetic Mice
AU - Husen, S. A.
AU - Winarni, D.
AU - Salamun,
AU - Ansori, A. N.M.
AU - Susilo, R. J.K.
AU - Hayaza, S.
N1 - Funding Information:
Authors would like to thank the Dean of Faculty of Science and Technology and the Head of Institute of Innovation and Research Universitas Airlangga for the given opportunity to conduct this research funded by the Directorate General of Higher Education, Ministry of Research, Technology, and Higher Education of the Republic of Indonesia which was granted to Saikhu Akhmad Husen (Associate Professor in Faculty of Science and Technology, Universitas Airlangga). Moreover, special thanks to PMDSU Scholarship - Batch III (Ministry of Research, Technology, and Higher Education of the Republic of Indonesia) which was awarded to Arif Nur Muhammad Ansori, Raden Joko Kuncoroningrat Susilo, and Suhailah Hayaza.
Publisher Copyright:
© 2019 Published under licence by IOP Publishing Ltd.
PY - 2019/1/9
Y1 - 2019/1/9
N2 - The aim of this study was to investigate whether gamma-mangostin could reduce fasting blood glucose, cholesterol, SGOT, SGPT, and also ameliorate damaged hepatocytes in diabetic mice. In this study, we used male BALB/C mice. Mice were divided into two groups: Normal control (KN) and streptozotocin-induced diabetic. Streptozotocin (STZ) induction was performed using multiple low doses of 30 mg/kg body weight injected for five consecutive days. The diabetic mice were separated into three subgroups: Diabetic control (KD), diabetic mice treated with acarbose (KA), and diabetic mice treated with gamma-mangostin at either 0,5 mg/kg body weight (P1), 1 mg/kg body weight (P2), or 2 mg/kg body weight (P3). Before and after STZ injection, fasting blood glucose and cholesterol level would be observed. Fasting blood glucose and cholesterol level were also measured at the 1 st , 7 th , and 14 th day of gamma-mangostin treatment. Treatment was given for 14 days. On the 15 th day, SGOT and SGPT were measured using a Pentra C 200 Reader, while the liver was collected and processed onto the histological slides. Interestingly, we found that gamma-mangostin was able to reduce the fasting blood glucose, cholesterol, SGOT, SGPT, and ameliorate the damaged hepatocytes in significant diabetic mice. Therefore, we concluded that gamma-mangostin is a promising anti-diabetic agent due to its anti-hyperglycemic and antioxidant activities.
AB - The aim of this study was to investigate whether gamma-mangostin could reduce fasting blood glucose, cholesterol, SGOT, SGPT, and also ameliorate damaged hepatocytes in diabetic mice. In this study, we used male BALB/C mice. Mice were divided into two groups: Normal control (KN) and streptozotocin-induced diabetic. Streptozotocin (STZ) induction was performed using multiple low doses of 30 mg/kg body weight injected for five consecutive days. The diabetic mice were separated into three subgroups: Diabetic control (KD), diabetic mice treated with acarbose (KA), and diabetic mice treated with gamma-mangostin at either 0,5 mg/kg body weight (P1), 1 mg/kg body weight (P2), or 2 mg/kg body weight (P3). Before and after STZ injection, fasting blood glucose and cholesterol level would be observed. Fasting blood glucose and cholesterol level were also measured at the 1 st , 7 th , and 14 th day of gamma-mangostin treatment. Treatment was given for 14 days. On the 15 th day, SGOT and SGPT were measured using a Pentra C 200 Reader, while the liver was collected and processed onto the histological slides. Interestingly, we found that gamma-mangostin was able to reduce the fasting blood glucose, cholesterol, SGOT, SGPT, and ameliorate the damaged hepatocytes in significant diabetic mice. Therefore, we concluded that gamma-mangostin is a promising anti-diabetic agent due to its anti-hyperglycemic and antioxidant activities.
UR - http://www.scopus.com/inward/record.url?scp=85060010561&partnerID=8YFLogxK
U2 - 10.1088/1755-1315/217/1/012031
DO - 10.1088/1755-1315/217/1/012031
M3 - Conference article
AN - SCOPUS:85060010561
SN - 1755-1307
VL - 217
JO - IOP Conference Series: Earth and Environmental Science
JF - IOP Conference Series: Earth and Environmental Science
IS - 1
M1 - 012031
T2 - 2nd International Conference on Collaboration Seminar of Chemistry and Industry, CoSCI 2018, in conjunction with 23rd Indonesian Society for Biochemistry and Molecular Biology, ISBMB 2018
Y2 - 11 October 2018 through 12 October 2018
ER -